Drotaverine injections 20mg/ml 2ml #10

Instruction for Drotaverine injections

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pharmachologic effect

Drotaverine injections are a derivative of isoquinoline, is similar in chemical structure and pharmacological properties to papaverine, but has a more pronounced and prolonged effect. Drotaverine injections has a pronounced antispasmodic effect on smooth muscles by inhibiting phosphodiesterase-4 (PDE-4). PDE-4 hydrolyzes cyclic adenosine monophosphate (cAMP) to adenosine monophosphate AMP. Inhibition of PDE-4 leads to an increase in the concentration of cAMP, which activates cAMP-dependent phosphorylation of myosin light chain kinase (MLCK). Phosphorylation of MLCC leads to a decrease in its affinity for calcium ions, the calmodulin complex, as a result of which the inactivated form of MLCC supports muscle relaxation. cAMP, in addition, affects the cytosolic concentration of calcium ions by stimulating the transport of calcium ions into the extracellular space and the sarcoplasmic reticulum. In vitro, Drotaverine injections inhibits PDE-4 isoenzyme without inhibiting PDE-3 and PDE-5 isoenzymes; therefore, the effectiveness of injections drotaverine depends on the activity of PDE-4, the content of which is different in different tissues. A high content of PDE-4 is noted in the bile and urinary tract, uterus, and gastrointestinal tract. Hydrolysis of cAMP in the myocardium and smooth muscles of blood vessels occurs mainly with the help of PDE-3, therefore Drotaverine injections has less effect on the cardiovascular system. injections Drotaverine are effective in spasms of smooth muscles of both neurogenic and muscular origin.

Indications for use

Spasms of smooth muscles in diseases of the biliary tract: cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis. Spasms of smooth muscles of the urinary tract: nephrolithiasis, urolithiasis, pyelitis, cystitis, bladder tenesmus. As an adjuvant therapy (when the form of tablets cannot be applied): with spasms of the smooth muscles of the gastrointestinal tract: peptic ulcer of the stomach and duodenum, gastritis, spasm of the cardia and pylorus, enteritis, colitis, irritable bowel syndrome; for gynecological diseases: dysmenorrhea; when conducting some instrumental studies, including cholecystography.

Contraindications for Drotaverine injections

Hypersensitivity to the active substance or to any of the excipients of the drug; • hypersensitivity to sodium disulfite; • severe hepatic or renal failure; • severe chronic heart failure; • AV block II-III degree; • childhood; • the period of childbirth; • breastfeeding period.

Dosage and administration

Intramuscularly in 2-4 ml (40-80 mg) 1-3 times a day. The course of treatment is 1-2 weeks. If necessary, long-term treatment is transferred to the reception of the drug inside the dosage form of the tablet. In acute colic (kidney or gallstone disease), 2-4 ml (40-80 mg) in 10-20 ml of 0.9% sodium chloride solution or 5% dextrose solution intravenously slowly (the duration of administration is approximately 30 seconds). Do not mix in the same syringe with a solution of aminophylline.

Release form

Solution for intravenous and intramuscular administration of 20 mg / ml. On 2 ml in ampoules of colorless neutral glass type I with a color ring of a break or with a color point and a notch or without a ring of a break, a color point and a notch. One, two or three color rings and / or two-dimensional bar code, and / or alphanumeric coding with or without additional color rings, two-dimensional bar code, alphanumeric coding can be additionally applied to the ampoules. On 5 ampoules in a blister strip packaging from a film of polyvinyl chloride and aluminum foil lacquered or polymer film or without foil and without film. Or 5 ampoules are placed in a pre-made form (tray) of cardboard with cells for laying ampoules. 1, 2, 10 or 20 blister packs or cardboard trays along with instructions for use and a scarifier or an ampoule knife, or without a scarifier and an ampulla knife are placed in a cardboard pack (bundle).

Terms of sell

You don't need a prescription to buy Drotaverine injections.