Ranitidine tabs 150mg #20

Ranitidine instruction

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Ranitidine is an antiulcer drug that blocks H2-histamine receptors.

Release form and composition

Dosage form - film-coated tablets: round, biconvex, light orange in color (in blister packs of 10 tablets, 2 blisters in a cardboard box).
Active ingredient: ranitidine (in the form of hydrochloride) - 150 or 300 mg in 1 tablet.
Auxiliary components: collidone VA-64, corn starch, colloidal silicon dioxide, propylene glycol, polyethylene glycol 6000, sodium lauryl sulfate, hypromellose, magnesium stearate, ethyl cellulose, microcrystalline cellulose, titanium dioxide, sunset yellow dye.

Pharmacodynamics

Ranitidine is a blocker of histamine H2 receptors of parietal cells that make up the gastric mucosa. It suppresses the basal and stimulated production of hydrochloric acid, caused by food load, baroreceptor irritation and the effects characteristic of biogenic stimulants (pentagastrin, gastrin, histamine) and hormones. Ranitidine helps to reduce the volume of gastric juice and the concentration of hydrochloric acid in it and increases the pH of the contents of the stomach. This explains the reduced activity of pepsin during treatment with the drug. The duration of its action after a single dose is about 12 hours.

Pharmacokinetics

When taken orally, the bioavailability of ranitidine is approximately 50%. The substance binds to plasma proteins by no more than 15% and partially participates in metabolic processes in the liver. Its maximum plasma content is reached 2 hours after taking the tablets. The half-life of ranitidine is 2-3 hours. About 30% of the accepted dose of the drug is excreted through the kidneys unchanged, a small amount of ranitidine through the intestines. The substance crosses the placental barrier and is determined in breast milk.

Indications for use

    Exacerbation of gastric ulcer and duodenal ulcer (treatment and prevention);
    Zollinger-Ellison Syndrome;
    Erosive esophagitis and reflux esophagitis;
    Gastric ulcer and 12 duodenal ulcer, developed as a result of taking non-steroidal anti-inflammatory drugs (NSAIDs);
    Postoperative and stressful ulcers of the upper gastrointestinal tract (treatment and prevention);
    Prevention of Mendelssohn syndrome (aspiration of gastric juice) during operations using general anesthesia;
    Prevention of recurrence of bleeding from the upper gastrointestinal tract.

Contraindications

Absolute:
    Children's age up to 12 years;
    The period of pregnancy and lactation;
    Individual hypersensitivity to components of the drug.
Relative:
    Liver cirrhosis with a history of portosystemic encephalopathy;
    Hepatic and / or renal failure;
    Acute porphyria, including a history of.

Instructions for use: method and dosage

The tablets should be taken orally: swallow whole and drink plenty of fluids. Eating does not affect the effectiveness of the drug.
Recommended dosages for adults and children over 12 years of age depending on indications:
    Peptic ulcer of the stomach and duodenal ulcer: treatment of exacerbations - 150 mg in the morning and evening or 300 mg at night, in some cases it is possible to increase the dose to 300 mg 2 times a day, the course of treatment is from 4 to 8 weeks; prevention of exacerbations - 150 mg once a day at night, for smoking patients - 300 mg at night;
    Peptic ulcer due to NSAIDs: treatment - 150 mg in the morning and evening or 300 mg at night for 8-12 weeks; prevention - 150 mg in the morning and evening;
    Postoperative and stressful ulcers: 150 mg 2 times a day for 4-8 weeks;
    Zollinger-Ellison syndrome: 150 mg 3 times a day, if necessary, increase the dose;
    Erosive reflux esophagitis: 150 mg in the morning and evening or 300 mg at night, in some cases, the doctor can increase the dose to 150 mg 4 times a day, the duration of therapy is 8-12 weeks. If necessary, prolonged preventive therapy is prescribed 150 mg 2 times a day;
    Prevention of recurrent bleeding from the upper gastrointestinal tract: 150 mg 2 times a day;
    Prevention of Mendelssohn's syndrome: 150 mg in the evening before surgery, then 150 mg 2 hours before anesthesia.
In renal failure (creatinine clearance less than 50 ml / minute), the daily dose should not exceed 150 mg.
Patients with concomitant impaired liver function may also require a reduction in the daily dose.

Side effects

    Allergic reactions: bronchospasm, skin rash, urticaria, anaphylactic shock, Quincke's edema, erythema multiforme;
    From the cardiovascular system: atrioventricular block, bradycardia, lowering blood pressure, arrhythmia;
    From the musculoskeletal system: myalgia, arthralgia;
    From the nervous system: headache, drowsiness, dizziness, increased fatigue; rarely - tinnitus, involuntary movements, irritability, confusion, hallucinations (more often in older people and severely ill patients);
    Hematopoietic organs: bone marrow hypo- and aplasia, agranulocytosis, immune hemolytic anemia, thrombocytopenia, leukopenia, pancytopenia;
    From the digestive system: dry mouth, abdominal pain, diarrhea / constipation, nausea and / or vomiting; rarely - acute pancreatitis, cholestatic, hepatocellular or mixed hepatitis;
    From the endocrine system: amenorrhea, gynecomastia, decreased libido, hyperprolactinemia, impotence;
    From the sensory organs: paresis of accommodation, blurred visual perception;
    Other: hypercreatininemia, alopecia.

Overdose

With an overdose of Ranitidine, the following symptoms may be observed: ventricular arrhythmias, bradycardia, convulsive seizures. In this case, symptomatic therapy is recommended, as well as gastric lavage and / or induction of vomiting. If convulsive seizures occur, diazepam is administered intravenously. With bradycardia, atropine is prescribed, and with ventricular arrhythmias, lidocaine is prescribed. Hemodialysis is considered an effective procedure for the removal of ranitidine.

Special instructions

Due to the fact that Ranitidine can mask the symptoms characteristic of carcinoma of the stomach, it is necessary to exclude the presence of oncology before its appointment.
During therapy, it is recommended to refrain from drinking drinks, food and medications that can irritate the gastric mucosa, as well as from driving a car and performing potentially dangerous work, requiring speed of psychophysical reactions and increased attention.
In debilitated patients with prolonged use of the drug under stress, bacterial gastric lesions are possible with the subsequent spread of infection.
Like all H2-histamine blockers, Ranitidine should not be abolished abruptly (there is a risk of developing a rebound syndrome).
If necessary, the simultaneous use of histamine H2 receptor blockers must be taken 2 hours after taking ketoconazole / itraconazole, otherwise a significant decrease in their absorption is possible.
According to the instructions, Ranitidine can increase the activity of glutamate transpeptidase.
There is some evidence that the drug can cause acute attacks of porphyria.
Histamine H2 receptor blockers can counteract the effects of histamine and pentagastrin on the acid-forming function of the stomach, so it is not recommended to use them within 24 hours before the test.
During treatment with Ranitidine, a false-positive reaction is possible when testing for the presence of protein in the urine.
Since H2-histamine receptor blockers can suppress the skin reaction to histamine, they should be canceled before performing diagnostic skin tests to detect an allergic skin reaction of an immediate type.

Drug interaction

It should be borne in mind that ranitidine:
    It inhibits the metabolism in the liver of indirect anticoagulants, calcium antagonists, aminophenazone, glipizide, diazepam, lidocaine, metronidazole, propranolol, phenazone, theophylline, hexobarbital, buformin, aminophylline, phenytoin;
    Increases serum concentration and half-life of metoprolol;
    Reduces the absorption of ketoconazole and itraconazole.
Smoking reduces the effectiveness of ranitidine.
With the simultaneous use of drugs that have a depressing effect on the bone marrow, the risk of neutropenia increases.
High doses of antacids and sucralfate can slow the absorption of ranitidine, so at least 2-hour intervals should be observed between doses.

Terms and conditions of storage

Store in a dry place inaccessible to children in compliance with a temperature regime of 15-30 ° C.
Shelf life is 3 years.

Reviews

The drug allows for a short period of time to stop pain in the epigastric region with ulcerative lesions of the gastrointestinal tract and gastropathy, which is due to a decrease in the acidity of gastric juice. Mostly positive reviews of ranitidine predominate, since it is well tolerated and does not cause adverse reactions when used in therapeutic doses. Many patients note such advantages of the drug as low cost and quick elimination of an attack of heartburn.
Ranitidine tablets can be used in emergency cases if the diet is not followed, which leads to exacerbations of gastritis or peptic ulcer. Some patients complain that it is strictly forbidden to take the drug during pregnancy and lactation.

Terms of sell

You can buy Ranitidine without a prescription.