Nolpaza tabs 40mg #56

Nolpaza instruction

You can buy Nolpaza here

Nolpaza is a medication that is part of the pharmacological group of proton pump inhibitors.
Its main quality, the ability to reduce the secretory activity of the stomach, which leads to a decrease in the production of hydrochloric acid. Also, this tool can be prescribed to fight the bacteria Helicobacter pylori.

Composition

The role of the active active ingredient is the substance Pantoprazole, which is part of the tablets in an amount of 20 to 40 mg.
In the powder used for injections, its proportion is 40 mg.
The composition of the drug includes additional ingredients:
    Sorbitol.
    Calcium stearate.
    Mannitolum.
    Sodium carbonate.

Release form

Nolpaza tablets 20-40 mg, in convolute for 14 pills, in cardboard packaging, in the amount of 28 pieces. Additionally attached annotation.

Pharmachologic effect

The main indication in which this drug is administered is hypoacid activity, the ability to reduce the enzymatic function of the stomach.
When prescribing the drug Nolpaza, its antibacterial effect on the pathogenic microflora of the stomach is taken into account. In the case of combined treatment with antibacterial drugs, its antimicrobial quality may increase.
This allows you to use it if the patient is affected by the stomach bacteria Helicobacter pylori.
When Nolpaza medicine gets into the human body, its action begins after 60 minutes, gradually accumulating, reaches its peak after 3 hours. After discontinuation of treatment, the remains of this compound are excreted for four days, mainly through the intestines.

Therapeutic effect

The main scope and purpose of Nolpaza is the treatment of stomach ulcers, which occur for various reasons. Also, because of the ability to lower acidity, it is often prescribed in the treatment of gastritis and esophagitis, reflux esophagitis.
Due to the fact that the production of hydrochloric acid is reduced, the mucous membrane of the stomach begins to heal, and the ulcers heal:
    The ability of Nolpaza to suppress the acidic environment, activates the effect of antibiotics on the bacteria Helicobacter pylori. This leads to their complete neutralization.
    When the treatment of pathological conditions occurs, as a result of which the gastric juice is refluxed into the esophagus (reflux gastritis, esophagitis), then the therapeutic effect is observed after 10 days of using this medication.
    Nolpaza significantly increases the level of gastrin, and normalizes its concentration in the bloodstream. This effect, gradually decreases after discontinuation of the drug, and comes to normal rates.

Indications

Peptic ulcer, this is not the only area of ​​application of this drug. It is prescribed for various pathological processes of the stomach and esophagus.
The tablet form and injection powder have the same effect.
Their appointment occurs in the following cases:
Diseases of the esophagus (gastroesophageal reflux disease, esophagitis, esophagospasm), which are characterized by the reflux of food from the stomach to the esophagus.
    In case of violation of the functions of the digestive system, due to which it appears:
        Belching with acid.
        Heartburn, which does not respond to treatment with conventional antacids.
        Spastic pain in the epigastric region.
        Increased flatulence, often accompanied by asymmetry of the abdomen and flatulence.
    Pathological processes, the result of which, was a peptic ulcer, or as a preventive measure to prevent relapse.
    Combination with antibiotic therapy, the purpose of which is to destroy the bacterial flora Helicobacter pylori.
    Diseases that significantly increase the concentration and production of gastric juice (Zollinger-Ellison disease).
    In the treatment of chronic pathological diseases of the musculoskeletal system, anti-inflammatory non-steroid medications are used. With their appointment, the causes of the inflammatory process are eliminated, but their tablet forms lead to the appearance of ulcers and erosion on the gastric mucosa. Nolpaza is used to prevent the development of such side effects. Protecting the gastric mucosa, it does not reduce the effects of antibacterial drugs

Instructions for use

The first thing to do when prescribing Nolpaza is to undergo an ultrasound examination and fluoroscopy. This will exclude malignant neoplasms in the patient’s digestive system. Since the subsequent intake of Nolpaza is able to smooth out the clinical manifestation of these diseases.
    An incorrect diagnosis can result in the development of severe pathologies. It must be borne in mind that this drug is able to reduce the absorption of vitamin B12 (Cyanocobalamin), therefore, to maintain its level in the circulatory system, it is necessary to prescribe it in the form of intramuscular injections, one ml daily.
    The use, dosage and duration of the course of therapy with Nolpaza is prescribed only by a doctor. It is based on the history, instrumental and laboratory studies. Basically, the purpose of the dosage depends on the general condition, age and the presence of hepatic or renal pathology.
    If tablet forms of Nolpaza are prescribed in a single dose, then it is better to take them on an empty stomach before breakfast for 15 or 20 minutes. In the case of the appointment of double use, the second pill is used before dinner.
    If Nolpaza is used for prophylactic purposes, preventing a recurrent form of peptic ulcer, Nolpaza is prescribed in a single dose of 20 mg in the morning.
    In severe pathological processes, the dose doubles, and its volume is 40 mg. Appointment Nolpaza recommended in the morning and evening hours.
    If a patient develops nausea, spastic pain in the lower abdomen, upset stool, then it is necessary to make changes in the purpose of the drug, take once in the amount of one tablet.
    In case of heartburn, which is accompanied by acid burping, this drug is used in the amount of 1 tablet (20 mg). If this dosage does not improve the patient's condition, it is increased to 40 mg, divided into 2 doses per day. The subsequent appointment of therapy will depend on the level of production of gastric juice, and the duration of treatment can be extended.
    When treating with non-steroidal, anti-inflammatory drugs, Nolpaza should be used throughout the course of treatment of NSAIDs. A daily dose is prescribed from 2 to 4 pills. On average, such therapy takes no more than 8 weeks.
    In order to neutralize the activity of Helicobacter pylori bacteria, it is necessary to undergo a course of treatment lasting up to 2 weeks, while the daily dose is divided into two doses, and its volume can reach up to 80 mg per day.
    If the patient has hepatic pathologies, then the appointment of treatment is carried out with constant monitoring of laboratory studies of liver enzymatic parameters.
    Elderly people are not prescribed Nolpaza. Only in rare cases, a dose is prescribed that does not exceed 40 mg within 24 hours.
Nolpaza can be used by intravenous injection, or by setting droppers. To make an intravenous injection, it is necessary to dilute the contents of the vial with ten milliliters of saline (0.9% sodium chloride).
For a dropper, the contents of the vial are dissolved in 100 ml of sodium chloride (0.9%), or glucose (0.5%) in the same volume. The dripping speed should not exceed 80 drops per minute. The ready-made solution for injections and droppers is used immediately, the delay is allowed no more than 12 hours.
In tablets and infusion solution, the same indications:
Parenteral administration of Nolpaza is used in more severe cases of therapy of pathological processes. Also, intravenous vision can be prescribed in cases where oral administration is not possible. The duration of intravenous injection may last for a week.
    Such therapy is prescribed for the treatment of Zollinger-Ellison syndrome. The recommended daily dose for this pathology does not exceed 80 mg.
    For the treatment of reflux esophagitis, esophagospasm, parenteral administration is also acceptable. Assigned to 40 mg (one bottle) once a day.

Pregnancy

The effect of Nolpaza on the body of a pregnant woman has not yet been adequately studied. In any case, the appointment of Nolpaza should be agreed with the attending physician. Only he can assess the risk of using this drug, and carefully weigh its benefits for the female body.
If an appointment still occurs, then this medicine is taken in minimal doses, with a short course of treatment.
During lactation - no data on the health effects of the newborn is available. Therefore, if therapy with Nolpaza therapy occurs, breastfeeding should be stopped.

Childhood

Due to the fact that clinical trials for children under 18 years of age have not been conducted, Nolpaza is not prescribed.

Vehicle management

If the patient’s work is associated with increased concentration of attention and is accompanied by the need to quickly respond to current situations, then in these cases it all depends on the individual tolerance of Nolpaza.
Sometimes it can cause sudden dizziness, when such a symptom appears, it is best to refrain from such work, take a sick leave, and undergo the full course of treatment prescribed by the doctor.
Alcohol compatibility
The annotation, which is attached to Nolpaza, does not contain any information on the interaction with alcoholic beverages. However, this does not mean that the use of alcohol-containing drinks is permissible.
When using them, the following undesirable consequences can be noted:
    There is a decrease in the level of therapeutic effect of Nolpaza, in the end, its effect can be reduced to zero effect.
    Alcoholic beverages lead to irritation of the gastric mucosa, and, as a result, increase its secretory function.
    If the patient's main diagnosis sounds like peptic ulcer, then the alcohol he uses does not allow scarring of ulcers.
    Whether alcoholic beverages can be provocateurs in the development of side effects, which will serve as a criterion for the abolition of Nolpaza.
Drinking alcohol is possible only when a full course of therapy has been completed and at least 4 days have passed after it (this is the term for withdrawal of Nolpaza),

Overdose

This negative consequence, in the treatment of various pathological conditions with this drug, is extremely rare. It can occur if the dose of the drug is not observed (most often, this happens with parenteral administration).
In this case, the clinical picture of poisoning develops. It is accompanied by the appearance of a severe headache, palpitations, the appearance of nausea or vomiting, excessive sweating, blanching of the skin.
If any signs appear, you must:
    empty the stomach (rinse it or induce vomiting);
    cleanse the intestines (deliver microclysters);
    take one of the drugs of the pharmacological group of enterosorbents (Polysorb, Enterosgel, Sorbex, Activated Carbon).
If, after carrying out these procedures, the condition did not improve, it is necessary to contact the clinic or sanitary inspection room. In especially serious cases, you need to call a doctor at home, he will make appointments that will eliminate the symptoms of poisoning.

Interaction with other drugs

Nolpaza may decrease the effectiveness of the following drugs:
A group of drugs whose absorption directly depends on the degree of acidity of the stomach. These include antifungal dosage forms (ketoconazole, itraconazole).
    The pharmacological group that is prescribed for the treatment of HIV-infected patients.
    Coumarin anticoagulants (Fenprokumon or Warfarin).
Some drugs, on the contrary, become more active when prescribing Nolpaza:
    Patients undergoing cancer therapy with methotrexate should stop using this drug for the duration of treatment with Nolpaza. Due to the fact that it is able to increase its concentration in the bloodstream.
    When using antibacterial therapy, Nolpaza potentiates the effect of antibacterial agents.
This drug does not have a significant effect when taken:
    Diclofenac and Dicloberl.
    Digoxin.
    Caffeine.
    Infinom.
    Piroxicam.
    Theophylline.
    Means of oral contraception.
Concurrent use of Pantoprazole and antacids is allowed. It is also possible its appointment along with antibiotics.

Contraindications

In Nolpaza, when it is prescribed, there are two types of contraindications:

Absolute

In this case, the reception and appointment of Nolpaza is not performed.
The following pathological conditions can be included in this group:
    The occurrence of an allergy to the ingredients of sodium Pantoprazole, or individual intolerance.
    Teenagers under the age of 18. The study has not yet been performed on this age category.
    If the dosage exceeds 40 mg, and the patient has severe liver or kidney disease, then the appointment of the drug can cause side effects.
    With a disorder that is caused by a violation of the psychoemotional state (depression of various etiologies).

Relative

This remedy is not recommended for patients with such pathologies (but with special care, under the supervision of medical staff, in a hospital, this remedy is sometimes prescribed).
List of pathologies:
    Extensive focal lesions of the gastric mucosa, in the treatment of which non-steroidal anti-inflammatory drugs are prescribed for a long time.
    Gastric bleeding that results from the development of ulcers and erosion.
    Try not to prescribe this dosage form to people of advanced age.
    In the event that vitamin B12 hypovitaminosis therapy is simultaneously performed using Cyanocobalamin, and it does not give positive dynamics.

Side effects

The drug of this pharmacological group is well tolerated by patients, but sometimes, with improper use and purpose, undesirable reactions can occur that appear in different body systems.
Let's consider in more detail:
The hematopoietic system may respond with thrombocytopenia or leukopenia.
In the digestive system, disruptions can occur that lead to severe damage to the liver tissue, and are accompanied by obstructive jaundice, cholestasis. Dryness of the mucous membranes of the oral cavity, nausea and vomiting, excessive gas formation (flatulence), upset stool (diarrhea or constipation), periodic pain in the abdomen can also occur.
With large doses of this medication, arthralgia and myalgia can develop in the bones and muscles.
Very rarely, on the part of the central nervous system in patients, with the appointment of Nolpaza, a psychoemotional state disorder is observed, it is accompanied by insomnia at night, drowsiness in the daytime, the appearance of migraine, blurred vision.
Often there are allergic reactions, they are accompanied by the appearance of skin itching and rashes. In severe conditions, erythema multiforme, Lyell's syndrome and Quincke's edema can develop.
Among the milder side effects can be noted the appearance of weakness, loss of strength, hyperthermia, chest pain, edema. With biochemical blood tests, there may be an increase in cholesterol, and the amount of triglycerides.

Storage

The shelf life of this dosage form is not more than 3 years from the time of its manufacture. During storage, it must not be allowed to be exposed to direct sunlight. And the place should be chosen so that the children do not have access to it.

Terms of sell

You don't need a prescription to buy Nolpaza.