Motilium susp 1mg/ml 100ml

Instruction for Motilium

You can buy Motilium here

Release form

Suspension. It is a jelly-like homogeneous white liquid with a sweet taste. Such a medicine is sold in glass vials, to which a dosage syringe is attached. There are two scales on the syringe for easy dosing. One bottle contains 100 ml of syrup.

Composition

Each of the variants of Motilium, as the main component that provides the therapeutic effect of this drug, contains a substance called domperidone. Its amount in 1 ml of suspension is 1 mg.
Additionally, the medication, depending on the form, includes:
    Sorbitol, polysorbate 20, sodium saccharin, sodium carmellose and other substances, due to which the suspension remains liquid, homogeneous and does not deteriorate.

Operating principle

Motilium has an antiemetic effect due to the action of its active ingredient on the central and peripheral structures involved in the formation of the emetic reflex:
    In the brain, the drug affects a specific area in the fourth ventricle called the trigger chemoreceptor zone. In this area, domperidone acts on dopamine receptors, as a result of which it impedes the conduction of impulses from the digestive tract to the vomiting center in the medulla oblongata. The medication acts on the trigger zone, since it is poorly protected by the blood-brain barrier.
    Domperidone almost does not get to other parts of the brain that are better protected, therefore side effects from the central nervous system are very rare in the treatment of Motilium (they often occur in babies due to increased barrier permeability).
    By acting on the digestive tract, the drug increases the tone of the sphincter, which separates the stomach from the esophagus, and also stimulates the motility of the stomach, as a result of which food leaves the stomach faster, passes into the duodenal zone and moves further down the intestine. In this case, the secretion of gastric juice under the action of domperidone does not change.
The active component of Motilium after taking a suspension or tablet is absorbed quickly enough and after 30-60 minutes its concentration in the bloodstream reaches its maximum level. Metabolic changes in domperidone occur in the liver, and the removal of the drug from the body partially occurs with urine (about 1/3), but to a greater extent, the drug is excreted in the feces.

Indications

Motilium is used for dyspepsia due to reflux of the contents of the stomach into the esophagus or too slow emptying of the stomach.
The medicine is in demand with:
    nausea
    pain in the epigastrium;
    flatulence;
    spitting up;
    heartburn;
    too fast saturation;
    a feeling of fullness in the stomach;
    vomiting
    bloating;
    belching with air or stomach contents.
The drug is prescribed for vomiting or nausea, caused by organic damage to the digestive tract, functional disorders of the stomach, intestinal infection, a violation of the diet (overeating, eating unusual food) or drug therapy.
    Motilium helps eliminate vomiting and nausea in patients taking bromocriptine and levodopa, as these drugs stimulate dopamine receptors.

At what age is allowed to take?

Motilium in liquid form is allowed from birth, since the suspension is easy to dose even for the smallest patients.
Solid forms of the drug are prescribed only from 5 years old and provided that the weight of the child exceeds the mark of 35 kilograms. With a weight of more than 35 kg and over the age of 5 years, you can use any of the types of tablets, choosing it depending on the preferences of the child.

Contraindications

The suspension is not prescribed if the child:
    There is intolerance to any of the components of the selected form of the drug, for example, lactose intolerance will prevent the use of tablets in the shell.
    A tumor was found to stimulate the release of prolactin (it is called prolactinoma).
    Diagnosed with gastric or intestinal bleeding, perforation of the gastrointestinal wall or intestinal obstruction (mechanical).
The drug is also not given to children with severe or moderate liver pathologies, and with a slight violation of the function of this organ, the drug should be used with caution, but the dosage does not change. The presence of a child’s kidney disease, heart failure, impaired electrolyte balance or problems with the conductivity of pulses in the heart requires a correction of the treatment regimen.

Side effects

    Taking Motilium in some children can provoke an allergy, and in very rare cases it causes an anaphylactic reaction.
    In infants, taking the medication sometimes leads to the appearance of nervousness and nervous excitement, as well as motor disorders and seizures.
    One of the actions of domperidone on the brain is to stimulate the release of prolactin in the pituitary gland, therefore, with Motilium treatment, it is possible to increase the concentration of such a hormone in the blood and the associated side effects.
    Rare side effects of the drug are called arrhythmia, urinary retention, diarrhea, headache, dry mouth, constipation, drowsiness, and other symptoms.

Instructions for use

    Drinking Motilium is recommended before meals, as food reduces the absorption rate of such a medication. The optimal time for taking both suspension and tablet forms is called 15-30 minutes before feeding.
    The suspension is carefully mixed before use to prevent the formation of foam. After collecting the medication with a syringe, it is given to the child, after which the syringe is washed with warm water.
    Infant babies and older children (up to 12 years old) suspension dosage is determined by weight, but you do not need to use a table for this. On a dosing syringe, which is in the package with the bottle, one scale from 0 to 20 kg and the second from 0 to 5 ml are marked. Therefore, when picking up the drug, you need to focus either on the body weight of the small patient, or on the right amount of milliliters. For each kilogram, children of this age require from 0.25 mg to 0.5 mg of domperidone, which corresponds to 0.25-0.5 ml of suspension. In this dose, the medicine is given three times a day, and sometimes four times the use is prescribed (an additional dose before bedtime).
    The maximum allowable amount of domperidone per day for children weighing> 35 kg is 80 mg, that is, 80 ml of suspension or 8 tablets. For children whose weight is less, to calculate the maximum daily dosage of liquid Motilium, multiply the number of kilograms by 2.4. For example, a child aged 2 years weighs 15 kg, which means that he can be given no more than 36 mg of domperidone per day (2.4x15 = 36), which is 36 ml of suspension. If you divide this dose into three doses, we get a maximum single dose of 12 ml, and if you give the drug four times a day, then no more than 9 ml per reception.
    If the child has serious kidney disease, the single dosage of Motilium does not change, but the frequency of administration is reduced to two times a day, and with severe renal failure, the medication is allowed to be given only once a day.

Overdose

If you accidentally exceed the dosage of Motilium allowed for children, this can adversely affect the nervous system of the small patient and cause disorientation, cramps, drowsiness, motor impairment, and other negative symptoms. In such a situation, you should rinse your stomach and seek medical help immediately.

Interaction with other drugs

Antacids and drugs that inhibit the secretion of gastric juice will impair the absorption of the drug, and under the influence of anticholinergics, the effect of the drug is neutralized. In addition, Motilium is not advised to combine with erythromycin, ketoconazole, amiodarone, clarithromycin, fluconazole and some other means. All medicines, with the use of which Motilium should be prescribed with caution, are noted in the annotation for liquid form and tablets.

Storage Features and Shelf Life

Keep Motilium at home in a dry place where the medication will be inaccessible to a small child. The optimal temperature regime for storing the drug is called the range from +15 to +30 degrees.
After opening the bottle, you do not need to place the bottle in the refrigerator (the drug is stored at room temperature).

Reviews

On the treatment of children with Motilium, you can find mostly positive reviews. In them, parents confirm that the medicine effectively copes with nausea, heartburn, heaviness in the abdomen, vomiting, and other uncomfortable symptoms indicating damage to the digestive system.
The medication showed itself well with rotovirus, esophagitis, cyclic vomiting, gastritis and other diseases. Motilium helps babies in their first year of life to get rid of increased gas formation, regurgitation and bloating. But in case of poisoning, many mothers noted the inefficiency of domperidone due to the fact that vomiting in this case is provoked by toxins that have got into the blood, so sorbents can cope with it much better.
The use of suspension, most mothers are satisfied. According to them, the medicine has a pleasant taste and is easy to dose due to the syringe present in the package. Parents also like the fact that the bottle is closed with a cap with a stopper, which most small patients cannot cope with, which prevents overdose. The main disadvantage of the suspension is its high price, which is why they often look for an analogue cheaper.
About the tablet form, too, speak mostly well. As with the suspension, many mothers complain about the high cost of the pills. In addition, sometimes the drug does not completely eliminate the discomfort, and another remedy is chosen for treatment.
    The rest of the medication is called effective and convenient to use. Side effects in the treatment of Motilium, according to parents, are rare.

Terms of sell

You can buy Motilium without a prescription.