Itomed tabs 50mg #40

Instruction for Itomed

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Itomed drug description

The modern drug Itomed belongs to the class of prokinetics, the main task is the correction of the activity of the gastrointestinal tract. As a result of taking the drug, patients have an increase in the motility of the digestive system, an improvement in metabolism. Release form - white tablets in the shell (blisters for 40, 100 pcs.)
The main active ingredient - Itopride hydrochloride - a highly effective stimulator of activity of the stomach, has a multifunctional effect:
    itopride blocks peripheral dopamine receptors, increasing the digestive system motility; inhibits a specific enzyme (acetylcholinesterase), increasing intestinal motility - thin, thick;
    has an antiemetic effect;
    positively affects the work of the upper gastrointestinal tract, contributing to the movement, digestion of food.
In gastroenterology Itomed is widely used in conditions of chronic gastritis; bloating (flatulence); pain in the stomach (gastralgia); heartburn; bouts of nausea, vomiting; not food perception. When using the drug, side effects are rare. The drug is contraindicated in pregnancy, breastfeeding.

Pregnancy and lactation use of the drug Itomed

Itopride is contraindicated in pregnancy. When taking the drug in therapeutic doses, itopride slightly penetrates into breast milk, so you should stop taking the drug during breastfeeding.

Side effects when taking Itomed

From the hemopoietic organs: infrequently - leukopenia; frequency unknown - thrombocytopenia. From the endocrine system: infrequently - hyperprolactinemia; frequency unknown - gynecomastia. From the digestive system: infrequently - diarrhea, constipation, pain in the epigastric region, increased salivation; frequency unknown - nausea, jaundice. From the nervous system: infrequently - headache, sleep disturbance. dizziness, irritability; frequency unknown - tremor.
    Allergic reactions: rarely - skin rash, redness, itching; frequency unknown - anaphylactoid reactions. From the urinary system: infrequently - an increase in the level of creatinine and urea nitrogen in the blood (BUN). From the musculoskeletal system: infrequently - pain in the chest or in the back.
Laboratory parameters: frequency unknown - increased activity of asparaginaminotransferase (ACT), alanine aminotransferase (ALT), gamma-glutamine transferase (GGT), alkaline phosphatase (NDF), hyperbilirubinemia. Other: infrequently - fatigue.

Recommendations for taking Itomed

Carefully read the instructions, contraindications, possible side effects. Clearly observe the dosage, time of administration. If you missed taking the pill, take it further, according to the schedule, and not a double dose. Be careful, attentive, concentrated at the wheel of vehicles, components can affect concentration.
With a constant, long-term appointment, visit your doctor to monitor, control the body. Stop taking it, contact the hospital for an early consultation, if your health has worsened, side effects have become noticeable after taking the drug.

Itomed tablets for gastritis

Active ingredient: Itopride hydrochloride 50 mg. Excipients: lactose monohydrate - 74.68 mg; pregelatinized corn starch - 5 mg; croscarmellose sodium - 1.8 mg; colloidal silicon dioxide - 1 mg; magnesium stearate - 2.52 mg. Film sheath: Opadry 85F18422 white - 3 mg (polyvinyl alcohol, partially hydrolyzed - 1.2 mg, titanium dioxide - 0.75 mg, macrogol 4000 - 0.606 mg, talc - 0.444 mg).
Itomed - stimulating tone and motility of the gastrointestinal tract, antiemetic. Enhances gastrointestinal motility due to antagonism with D2-dopamine receptors and inhibition of acetylcholinesterase. It activates the release of acetylcholine, inhibits its destruction. It has an antiemetic effect due to interaction with D2 receptors located in the trigger zone. Causes dose-dependent inhibition of apomorphine-induced vomiting.
It activates the propulsive motility of the stomach due to antagonism with D2 receptors and dose-dependent inhibition of acetylcholinesterase activity. It has a specific effect on the upper gastrointestinal tract, accelerates the transit through the stomach, improves its emptying. It does not affect the serum concentration of gastrin.
Quickly and well absorbed in the digestive tract. The relative bioavailability of the drug is 60%. Cmax - 0.28 μg / ml, after taking 50 mg of the drug Tmax in plasma - about 0.5-0.75 hours. With repeated use of 50-200 mg 3 times a day for 7 days pharmacokinetics is linear in nature, cumulation is minimal.
It binds to plasma proteins (mainly with albumin) by 96%, with α1-acid glycoprotein by less than 15%. It is actively distributed in tissues (Vd - 6.1 L / kg) and is found in high concentrations in the kidneys, small intestine, liver, adrenal glands, and stomach. In therapeutic doses, it slightly penetrates the brain and spinal cord, breast milk.
It is metabolized in the liver under the influence of flavin-dependent monooxygenase. 3 metabolites have been identified, one of which exhibits insignificant activity: 2-3% of the activity of itopride. It is excreted by the kidneys. T1 / 2 is 6 hours, in patients with trimethylaminuria T1 / 2 is increased.

How to take a course of administration and dosage for gastritis

Inside, before meals, 1 tablet 3 times a day. The daily dose is 3 tablets (150 mg). In elderly patients, the dose is reduced. If the drug was not taken on time, then in the future it should be taken at regular intervals. It is not recommended to take in a double dose to compensate for the missed.
Use with caution in patients taking cholinesterase inhibitors and m-cholinomimetics; as well as elderly patients with reduced liver and kidney function. If symptoms of galactorrhea and gynecomastia manifest, it is necessary to interrupt or completely discontinue treatment. In the treatment of primary biliary cirrhosis, transient decompensation of cirrhosis of the liver may occur, which disappears after discontinuation of the drug.

Reviews about Itomed in the treatment of gastritis:

    Antonina
I have chronic gastritis and exacerbation periodically occurs. During such periods, the gastroenterologist most often prescribes Itomed to me. This drug helps me very well, it is quite serious in its effect. I usually take it 1 tablet before meals three times a day. I feel much better. This drug perfectly removes heartburn and bloating, stimulates gastrointestinal motility. In general, when I drink this drug, I don’t even remember about gastritis. But taking it for a long time is also not recommended. So that the positive effect does not turn into a negative one. I noticed that if you drink it for more than 2 weeks, then pains begin in the epigastric region. Therefore, everything is good in moderation;
    Tatyana
This drug helped me cope with dyspepsia, made up for the lack of saliva, and improved the function of the digestive tract. Saw it for a month. Only the head is plague and the reaction is slowed down from him;
    Maxim (gastroenterologist), 28 years old
Itomed is an effective medication to improve the motor activity of the gastrointestinal tract. Suitable for both therapeutic and surgical practice. Taking pills helps to eliminate the feeling of fullness of the stomach, heartburn, belching, nausea, flatulence and other unpleasant symptoms. It can be used in long courses. The medicine has a number of contraindications, therefore it should be used only as directed by the doctor;
    Anna, 32 years old
Itomed received the husband. The doctor included this tool in the complex therapy of erosive gastritis. The drug is effective, satisfied with the result. But I want to note such a lack of medication as high cost.

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