Esslial Forte caps 300mg #90

Esslial Forte user manual

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Esslial forte is a drug that promotes the natural regeneration of liver cells.

Release form and composition

Dosage form Esslial forte - capsules: size No. 0, hard gelatinous, light brown body, dark brown cap; the capsules contain a brown or yellow-brown homogeneous mass with a characteristic odor and consistency from greasy to denser (in a cardboard box 1-6, 9 or 10 blisters of 5, 6 or 10 capsules or 1 can of 10, 20, 30, 40, 50, 60, 90 or 100 capsules).
Composition of 1 capsule:
    active substances: polyunsaturated phospholipids from soy lecithin - 300 mg (in the form of lipoid PPL-400 - 400 mg);
    auxiliary component: 95% ethanol - 4 mg;
    capsule (body / lid): titanium dioxide - 3 / 0.333 3%; dye iron oxide red - 0.01 / 0.93%; dye iron oxide yellow - 0.171 4 / 0.2%; black iron oxide dye - 0.01 / 0.53%; gelatin - up to 100/100%.

Pharmacodynamics

Essential phospholipids are the main elements of the structure of cell organelles and the membrane of liver cells. In liver diseases, damage to the membranes of hepatic cells and their organelles always occurs, which is the cause of disturbances in the activity of enzymes and receptor systems associated with them, a decrease in the ability to regenerate and a deterioration in the functional activity of liver cells.
The phospholipids that are part of Esslial forte in their chemical structure correspond to endogenous phospholipids, but surpass them in activity, which is associated with a higher content of essential (polyunsaturated) fatty acids. When these high-energy molecules are incorporated into the damaged areas of the cell membranes of hepatocytes, the integrity of the liver cells is restored and the ability to regenerate is improved.
Due to the cis-double bonds of polyunsaturated fatty acids, parallel arrangement of hydrocarbon chains in the phospholipids of cell membranes is prevented, and the density of the phospholipid structure of the cell membranes of hepatocytes decreases. This leads to an increase in their elasticity and fluidity, improves metabolism. Due to the formed functional blocks, the activity of enzymes fixed on the membranes increases, which contributes to the normal, physiological pathway of the most important metabolic processes.
Phospholipids, which are part of the drug, transfer neutral fats and cholesterol to oxidation sites, as a result of which lipoprotein metabolism is regulated. These processes occur mainly by increasing the ability of high density lipoproteins to form bonds with cholesterol.
When phospholipids are released into bile, its stabilization and a decrease in the lithogenic index are observed.
Esslial forte generally has a normalizing effect: on the detoxification function of the liver and phospholipid-dependent enzyme systems; on the metabolism of proteins and lipids. Ultimately, the drug prevents the formation of connective tissue in the liver and promotes the physiological recovery of liver cells.

Pharmacokinetics

Absorption of taken orally phospholipids (more than 90%) occurs in the small intestine. Most of it is cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine, 1/2 of which is immediately converted into polyunsaturated phosphatidylcholine (by reverse acetylation; the process takes place during absorption in the intestinal mucosa). With the flow of lymph, this polyunsaturated phosphatidylcholine enters the bloodstream, then enters the liver, mainly in the form associated with high density lipoproteins.
Studies of pharmacokinetic processes were carried out using dilinoleoyl-phosphatidylcholine. The maximum concentration of the choline component (radioactive 3H label) is 19.9% ​​of the dose received, it is reached in 6-24 hours. The maximum concentration of the linoleic acid residue (radioactive label 14C) is up to 27.9%, the time to reach it is from 4 to 12 hours. The half-life is 66 and 32 hours, respectively.

Indications for use

    alcoholic hepatitis;
    cirrhosis of the liver;
    chronic hepatitis;
    toxic liver damage;
    fatty degeneration of the liver of various etiologies;
    dysfunction of the liver against the background of somatic diseases;
    toxicosis during pregnancy;
    radiation syndrome;
    gallstones (to prevent the recurrence of their formation);
    psoriasis (as adjuvant therapy).

Contraindications

    soy intolerance;
    age up to 12 years;
    individual intolerance to the components of the drug.

Instructions for use Esslial forte: method and dosage

Esslial forte is taken orally, preferably with meals. Capsules should be swallowed whole, without chewing or chewing, with sufficient water (about 200 ml).
Adults and children over 12 years old with a weight of 43 kg are recommended to take 2 capsules 3 times a day.
There are no restrictions on the duration of the course.

Side effects

During the period of therapy, the following side reactions may occur:
    digestive system: rarely (> 0.01% and <0.1%) - gastralgia, discomfort in the epigastric region, nausea, loose stools;
    allergic reactions: very rarely (<0.01%) - exanthema, rash, urticaria; with an unspecified frequency - itching.

Pediatric use

According to the instructions, Esslial Forte is contraindicated in patients under 12 years of age.

Terms and conditions of storage

Store in a place protected from light at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.

Reviews about Esslial Fort

According to reviews, Esslial Forte contributes to the rapid restoration of liver function. Most patients note that the drug compares favorably with similar drugs in terms of price / quality ratio. They also indicate the convenience of use, the absence of side effects and restrictions on the duration of admission.

Terms of sell

You don't need a prescription from a doctor to buy Esslial Forte.