Dexilant caps 30mg #28

Instruction for Dexilant

You can buy Dexilant here

Release form, components

Dexilant - tablets like modified-release capsules, available in 30 and 60 mg packaging forms. Gray-blue colored tablets marked on the TAP case and marked with the concentration of the active component. Inside the capsule is a powder in the form of white granules.
Active ingredient: dexlansoprazole.
Additional components: sugar grains (a mixture of corn starch and sucrose), citric acid ester, magnesium carbonate, a copolymer of methyl methacrylate and methacrylic acid, sucrose, colloidal silicon dioxide, low substituted hyprolose, polysorbate 80, hyprolysis, hypromellose, etc.
Shell: carrageenan, potassium chloride, titanium dioxide, dyes, gray ink for marking.

Description

Dexilant is a drug that suppresses the secretion of digestive juice, delaying the last stage of hydrochloric acid production. The capsule of the medication breaks down in the stomach, releasing acid-resistant granules. The active substance leaves them at a suitable pH in different parts of the small intestine. This combination gives a prolonging effect, reducing the release of gastric juice for a long period.

Mechanism of action

The active component of Dexilant is easily absorbed after taking. It has high bioavailability, which reaches 76% or more. The combination of two components provides absorption in different pH phases. The maximum accumulation of the active component appears in the first hour - two from the time of adoption, the second release period begins in the range of 4 - 5 hours. After 5 days of using the drug, the highest concentration of the drug in serum and blood reaches 658 - 1397 ng / ml.
Connection with plasma proteins reaches 96.1 - 98.8%.
The active component is intensively processed by the liver, to inactive substances, due to oxidative and reducing processes with the formation of sulfates, glucuronides and glutathione compounds.
Oxidative processes occur with the help of cytochrome enzymes, which take part in hydroxylation and oxidation.
The period of time for which the concentration of the drug is reduced by half in the body takes 1-2 hours.
Complete cleansing of the body after 5-day treatment occurs at 11.4 and 11.6 l / h in accordance with the dosage.
The drug is excreted through the kidneys (up to 51%), and 48% removes the intestines.
Due to the fact that dexlansoprazole is processed by the liver, patients with impaired renal function do not adjust the dose of Dexilant.

Indications

According to the instructions for use, Dexilant is prescribed:
    For the treatment of all forms of erosive esophagitis.
    In order to support the therapeutic result after treatment of erosive esophagitis and get rid of the symptoms of heartburn.
    To eliminate signs of gastroesophageal reflux and non-erosive reflux esophagitis.

Contraindications

It is not allowed to take Dexilant for people who are allergic to one or more of its constituent components.
Women bearing a child and the period of breastfeeding.
Children under the age of 18.
Dexilant used with HIV protease inhibitors reduces their bioavailability, due to the dependence of absorption on the pH of the stomach.
Extremely carefully prescribed for use by patients undergoing therapy with Tacrolimus, inhibitors of the CYP2C19 isoenzyme - Fluvoxamine, Methotrexate and Warfarin, conducting mandatory monitoring of the prothrombin period and INR.

Method of administration, dosage

Dexilant capsules are prescribed orally at any time period, independent of food. It is allowed to uncork a capsule, pour granules on applesauce and swallow without chewing.
For the treatment of all forms of erosive esophagitis, a pharmaceutical agent is used at 60 mg per day for up to 2 months.
To maintain the result after treatment of erosive esophagitis and relieve signs of heartburn, 30 mg of the drug is recommended per day, prolonging the intake for up to six months.
To cure the moderate and severe form of erosive esophagitis, 60 mg per day is attributed for six months.
In order to treat signs of gastroesophageal reflux, a pharmaceutical agent of 30 mg per day for a month is prescribed.
For patients with impaired hepatic function, dexlansoprazole is recommended no more than 30 mg per day.
The elderly and patients with a disorder in the work of the kidneys and liver of the lungs do not need individual dosage selection.

Overdose

Information about the serious consequences of exceeding the permitted dose of Dexilant is not recorded. Numerous pharmaceutical preparations up to 120 mg and a one-time dose of 300 mg did not cause any dangerous adverse reactions. An increase in blood pressure to 140/90 mmHg from taking dexlansoprazole 60 mg 2 times a day was recorded. In case of an overdose with the appearance of unwanted reactions, treatment is carried out according to the symptoms.
Hemodialysis to remove from the body the active component of the medication is not possible.

Adverse reactions

Often, the use of Dexilant for treatment causes the following undesirable effects: increased gas formation, nausea, indigestion, vomiting, respiratory infections.
There are other rare adverse reactions:
    Anaphylaxis, hypersensitivity, dermatitis, malignant exudative erythema.
    Pain in the abdomen, abnormal noise in the intestines, diarrhea, constipation; rarely there is a feeling of drying out in the mouth, vomiting, candidiasis of the mouth, pancreatitis.
    Infrequent disorders of the liver functions, drug hepatitis are fixed.
    Rashes, irritations on the skin, urticaria on the integument, subcutaneous lupus erythematosus, leukocytoclastic vasculitis and generalized rash are rarely noted.
    Infections of the upper respiratory organs, cough is rarely noted, a feeling of constriction in the throat.
    Violation of taste buds, sensation of heat, goosebumps, tingling.
    Imbalance, hearing loss.
    Insomnia, depression.
    Anemia, thrombocytopenic purpura (idiopathic).
    Changes in sinus rhythm, angina pectoris, increased heart rate, rhythm and heart rate disorder, chest pain, myocardial infarction.
    Stroke, cephalgia, muscle spasm.
    Visual impairment, blurred.
    General disorders - swelling, lack of appetite, weakness.

The action of Dexilant with other medications

A pharmaceutical can be prescribed to patients undergoing clopidogrel therapy without additional dosage adjustment. No effect or interaction was recorded with the concomitant use of Diazepam, Theophylline, Phenytoin with a medication.
Taking dexlansoprazole capsules disrupts the absorption of medications that are dependent on the pH of the stomach, such as iron salts, Ampicillin, Digoxin, Ketoconazole, Erlotinib esters.
Taking it in tandem with Tacrolimus in patients after organ transplantation contributes to the accumulation of Tacrolimus in plasma.
Concurrent administration of dexlansoprazole and fluvoxamine increases the likelihood of a systemic effect of the former.
The use of Dexilant with methotrexate leads to the growth and conservation of a high percentage of accumulation of methotrexate and its residues in blood plasma. In need of high-dose therapy, the instruction recommends temporarily stop the use of dexlansoprazole.

Pregnancy, lactation

Therapy of pregnant women with this medicine is not recommended. If treatment with a drug during the lactation period is necessary, then lactation should be completed.

Children

For children under the age of 18 Dexilant is not prescribed.

Special instructions

Before you start using Dexilant, you need to make sure that there are no cancerous tumors, because it hides the signs and complicates the establishment of a residual diagnosis.
If symptoms persist even after treatment, an additional examination is required.
Dexlansoprazoles increase the risk of digestive tract infections caused by the bacterium Clostridia difficile, and are accompanied by diarrhea. This should be taken into account if diarrhea therapy does not give positive results.
Therefore, patients are prescribed a dose in minimally effective concentrations in short courses.
In patients with the recommended maximum doses with prolonged treatment with dexlansoprazole, there is a chance of fracture of the tibia, spinal column, and brushes throughout the year. People with this predisposition should not violate appointments.

Storage conditions

Dexilant is stored in a dry place without access to solar radiation in the temperature range up to 25 ° C, away from children.
The suitability of the drug in the bottle is 4 years, in blisters - 3.

Terms of sell

You don't need a prescription to buy Dexilant.