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Nifedipine instruction

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Nifedipine belongs to the group of dihydropyridine derivatives, one of the types of the drug group of calcium antagonists, which have a similar mechanism of action on the body, but have different effects on the heart and differing pharmacological properties. A feature of the therapeutic effect of Nifedipine is a decrease in pain in the chest, accompanied by a decrease in blood pressure. The drug has a long-term therapeutic effect, due to the slow degree of absorption, therefore, a single dose during the day is quite enough. The maximum degree of concentration in blood plasma reaches five hours after use, and excretion occurs along with urine and feces.
Nifedipine is today manufactured under the brand name of the Irish pharmaceutical corporation Allergan, Plc better known as Actavis. The company is headquartered in Dublin and is widely recognized as one of the leaders in the pharmaceutical market. The corporation's products are popular in many countries of the world, including Russia.

Dosage form and pharmacological properties

Nifedipine is manufactured and sold as round, yellow, film-coated tablets for oral administration. The tablets are packed in aluminum blisters, ten pieces each. One package with a medicinal product contains five such blisters, which is equal to the volume of fifty tablets in a pack. In addition to the medicinal product, instructions for use are placed in the package, which serves as a source of important information regarding the composition, indications for use, dosage regimen, contraindications, as well as the method of storage of the drug.
One tablet of the drug contains Nifedipine in various dosages: ten or twenty milligrams. To enhance the therapeutic effect, Nifedipine also contains components such as lactose monohydrate, cellulose, magnesium stearate, starch, talc and gelatin.

Indications for use

Nifedipine is recommended for use in the event of a number of symptoms and diseases of the cardiovascular system, including arterial hypertension of various types, angina pectoris, cardiomyopathy and other heart diseases, primarily affecting the myocardium. An effective agent for the prevention of myocardial infarction and coronary heart disease, reduces the likelihood of death from diseases affecting the heart muscle. It is used both as a component of complex therapy and treatment, and as an agent prescribed separately, without combining with other drugs.
Before using the drug, you need to consult a doctor, undergo all the necessary examinations and tests in order to establish an accurate diagnosis and confirm the presence of indications for starting the drug intake.

Method of administration and dosage

Nifedipine is administered orally, by swallowing a tablet with a medicinal substance, without crushing or chewing, with water. The initial dose of the drug is set at ten milligrams of Nifedipine per day, used two to three times a day, regardless of the time, both before and after meals. In the future, the dosage can be increased to forty milligrams of the drug at a time, also two or three times a day. Dosage adjustment to a lower value is required for elderly patients, as well as for people with impaired renal function or receiving antihypertensive therapy.
It is permissible to use the drug by placing it under the tongue in cases where it is necessary to stop an attack of a hypertensive crisis. In such a situation, the pill placed under the tongue dissolves within thirty or forty minutes, until the attack is suppressed. In this case, the patient should be in a horizontal position.
The course of treatment is determined personally by the doctor based on the tests, examinations and the established diagnosis. All appointments of the dosage regimen, as well as its changes, should be carried out under the clear guidance of a physician and on the basis of his recommendations.

Overdose and side effects

The antihypertensive effect of the drug causes an excessive decrease in blood pressure in case of violation of the dosage regimen specified in the instructions. Headache, heart rhythm disturbances, nausea and vomiting may also occur. In such situations, you should take activated charcoal and make a gastric lavage. Effective in such cases, calcium, which is slowly injected intravenously, and then infusion. Stick to the established recommended doses and do not exceed them, so that the treatment will bring only positive results.
In some cases, nifedipine can provoke the onset of symptoms and conditions such as fever, dizziness, fatigue, disturbed sleep and wakefulness, disorders of the gastrointestinal tract, myalgia, anemia, hyperglycemia. Allergic reactions may also appear in the form of skin redness, itching, urticaria and angioedema.

Contraindications to use

Nifedipine is not recommended for patients with increased susceptibility to the constituent components of the drug, as well as in acute myocardial infarction and cardiogenic shock. Do not use when blood pressure drops below ninety millimeters of mercury. The use of the drug is prohibited in the presence of stenosis of the aorta and other arteries, cardiac arrhythmias, weakness of the sinus node.
The use of the drug is not recommended for pregnant women, as well as during lactation. The possible risks to the health of the fetus and the benefits to the mother should be weighed, if the former prevail, it is necessary to refrain from taking the drug.
Use with caution in patients with liver and kidney disease and obvious disorders of their functioning.
During the period of using the drug, it is strictly forbidden to drive a car and other vehicles due to the fact that it causes symptoms such as dizziness and drowsiness. Violation of this warning may entail a threat to both the health of the patient himself and the health of those around him.

Interaction with alcohol and drugs

The combined use of the drug Nifedipine with alcohol is not recommended, since in patients with cardiovascular diseases this can lead to an increase in symptoms due to the antihypertensive effect.
It is forbidden to combine the drug with diuretics, antidepressants, fentanyl. A pronounced decrease in blood pressure develops when used simultaneously with magnesium-containing drugs. Able to increase the content of digoxin in the blood plasma, if combined with it.
Do not use concomitantly with angiotensin receptor blockers. Use in conjunction with beta-blockers should be under close supervision of the attending physician. The therapeutic effect of the drug is weakened by rifampicin.
Any drug interactions should be carried out only under the strict supervision of a physician to prevent a threat to the patient's health.

Terms of sell

You can buy Nifedipine without a prescription from a doctor.