Metoprolol tabs 50mg #60

Instruction for use of Metoprolol

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Indications

The drug has several indications for use, not only as an independent drug, but also in combination with other drugs. According to the instructions for use, Metoprolol has shown an effective effect in a number of the following diseases: • high blood pressure, which is observed in a patient for a stable long period of time; • angina pectoris or angina pectoris; • pathological impairment of myocardial blood supply; • various heart ailments, starting with the initial and ending with the chronic stage; • violation of the frequency, rhythm and sequence of heart contractions, including supraventricular, sinus and atrial tachycardia; • cardiomyopathy. In addition, Metoprolol is widely used as a prophylactic agent, preventing myocardial infarction, as well as relieving headaches. In combination with other drugs, it has successfully shown itself in the treatment of hyperfunction of the thyroid gland, due to an increase in certain hormones. Reduces the manifestation of akathisia caused by various antipsychotics.

Release form, composition and packaging

The medicine contains in its composition a single main component with the same name. Auxiliary "helpers" are microcrystalline cellulose, potato starch, povidone, talc, magnesium stearate and sodium starch glycolate. Metoprolol is produced in tablet form in several dosage options, as well as in the form of an injection solution. The flat-cylindrical tablet is painted in a snow-white shade. Slight color variation is allowed, both externally and in section. On one side of each unit, you can find a small thin pattern for easy breaking if the patient needs to drink only half. The drug is marketed in dosages of 25 mg, 50 mg and 100 mg. The tablets are in metal blisters, ten pieces each. A cardboard box may contain three or more plates.

Contraindications

Before you start taking Metoprolol, you should definitely consult with your doctor, since the remedy has a fairly impressive list of contraindications. It is strongly not recommended to use the drug without undergoing special studies and the appointment of the attending physician. German Metoprolol is absolutely contraindicated in patients who have the following diseases: • individual intolerance to beta blockers, the main substance and to the additional components included in the composition; • sick sinus syndrome; • decompensated heart failure, including pulmonary edema and arterial hypotension; • rare heart rhythm, when the patient's heartbeats decrease to 40 beats per minute or there are pauses of several seconds between beats; • complication of myocardial infarction, including cardiogenic shock; • circulatory disorders in the area of ​​the peripheral vascular bed, which includes arteries, arterioles, capillaries, venules, veins, etc. • high blood pressure when the indicator reaches 100 and above; • the presence of bronchial asthma and other pulmonary diseases of various origins; • accumulation of acids in the body, the cause of which is the deterioration of natural excretion from the body; • oncological diseases, including pheochromocytoma; • beta receptor therapy for a long time; • parallel treatment with inhibitors; • pregnancy and lactation. Also, Metoprolol is prohibited from prescribing to those patients who are administered intravenous injections of calcium antagonists and various arrhythmic drugs.

Dosage

According to the results of numerous clinical studies and reviews, Metoprolol does not lose its effectiveness depending on the meal. The drug can be taken both during meals and after the completion of the event. The tablet must be taken with a sufficient amount of liquid without chewing. The dosage and duration of treatment with Metoprolol primarily depends on the disease and the stage of its course. In the description of the medication it is said that with high blood pressure, the patient should consume up to 150 mg per day. This dosage can be divided into several doses. If relief is not observed, the doctor increases the dose by a maximum of another 50 mg. In the case of angina pectoris, start with a minimum dosage of 50 mg up to three times a day. In case of impaired attention, motor activity and too impulsive behavior in adults, the medicine is given at 50 mg once a day. If the effect of Metoprolol medication is not enough, a healthcare professional can double the daily intake. Tachycardia assumes the presence of the main active substance in the body of no more than 50 mg two to three times every 24 hours. In case of urgent need, Metoprolol is given daily up to 300 mg. For rapid relief of supraventricular tachycardia in the hospital, the patient is slowly injected with Metoprolol in a dosage of up to 5 mg. If there is no proper relief, the injection is repeated after five minutes. A daily dosage of more than 15 mg does not give the expected efficacy. As soon as the attack has been removed, the patient is transferred to the tablet form of the course, starting with 50 mg four times a day. For prophylactic purposes, the drug is also prescribed an average of 200 mg per day. Depending on the stage of the disease, the dosage can be either decreased or increased.

Side effects

Like all medicines, Metoprolol, along with a positive effect on the human body, in some cases can play a negative role: • the beginning of a therapeutic course in a patient is accompanied by slight weakness, rapid fatigue and frequent migraines; • extremely rarely, patients have short-term muscle cramps and sensory disorders in the limbs, expressed in tingling, goose bumps, burning or, conversely, cold; • metabolic disorder in the body, accompanied by weight gain; • decrease in the number of leukocytes and platelets in the blood; • an unreasonable increase in anxiety, which is expressed in depression, nightmares, memory disorders, confusion, nervousness and even hallucinations; • visual impairment and a feeling of dryness in the eyes, sometimes conjunctivitis occurs in patients; • feeling of sounds that do not exist in reality, for example, such as noises and ringing; • cases were recorded once when patients had different degrees of blockade, pain in the chest, increased symptoms in heart failure, tachycardia, impaired cardiac conduction function, cardiogenic shock with myocardial infarction, as well as circulatory disorders in the periphery; • the presence of shortness of breath during physical exertion and the appearance of rhinitis; • episodically, patients experience a feeling of nausea, which is accompanied by vomiting, as well as abdominal pain, abnormal stool frequency, heartburn and bloating.

Overdose

If too large a dosage of the main component of Metoprolol has been consumed, the stomach should be washed out immediately. After that, up to 2 mg of atropine sulfate is injected intravenously, if the patient is diagnosed with bradycardia or a violation of atrioventricular conduction. In the case of a decrease in myocardial contractility, therapy is prescribed from glucagon and dobutamine, which are also administered intravenously. With an increase in blood pressure - adrenaline, and with convulsions - diazepam. First of all, in order to detect an overdose of Metoprolol, a person needs to pay attention to the appearance of certain symptoms. This can be a strong and sharp decrease in blood pressure, a significant lengthening of the intervals between heartbeats. Sometimes, an overdose leads to a complication of myocardial infarction, up to the death of the patient. In addition to the above, a significant increase in the dosage of the drug Metoprolol can cause severe dizziness with possible loss of consciousness, respiratory arrest, excessive fatigue, the onset of convulsions and tremors, esophageal spasms accompanied by nausea and vomiting, as well as a negative effect on kidney function. The drug should be taken in the dosage prescribed by the attending physician. It is strongly discouraged to increase the daily dosage on your own.

Drug interactions

Metoprolol can be combined with other medicines of various spheres of influence, but such a tandem must necessarily be prescribed only by an experienced physician. The thing is that Metoprolol is definitely “friends” with certain medications, but it comes into conflict with others, which primarily affects the patient's health. For example, sympatholytics, nifedipine, nitroglycerin, diuretics and other antihypertensive substances, together with the main component of the drug, may well provoke a sharp decrease in blood pressure to a perceptible limit for a person. Such a decrease can be dangerous not only for health, but also for life in general. Anesthetic and antiarrhythmic drugs dramatically increase the patient's risk of developing an even greater heartbeat disorder and hypotension. With extreme caution, Metoprolol should be taken together with verapamil or diltiazem, since simultaneous intravenous administration in most cases ends in cardiac arrest. For insulin-dependent diabetics, the drug should definitely not be taken on its own. The drug reduces the effective action of insulin and many other antidiabetic agents, which leads to a sharp decrease in blood glucose levels. Some oral contraceptives increase the level of the main "ingredient" in the blood, and this fact should be taken into account by those patients who, taking into account the diseases, must adhere to a clear dosage. When taken simultaneously with indomethacin or other drugs of a similar action, the antihypertensive effect is significantly reduced.

Special instructions

Since Metoprolol is a beta-blocker, heart rate and blood pressure should be monitored regularly throughout the course of treatment. To begin with, the diagnosis should be carried out daily, and after the doctor is convinced of the positive dynamics, you can go to the check once a month. If the patient is prescribed a surgical intervention, then the drug is canceled no later than 48 hours before the estimated date of the operation. But in some cases, the medical professional does not remove the drug intake, even if an operation is to be performed. Metoprolol has an excellent ability to reduce arrhythmogenic effects and significantly reduce coronary circulation, which is especially important in surgical stress. In this case, an anesthetic with a weak negative isotropic effect should be selected for such a patient. Only then is such a tandem capable of exerting a depressing function on the myocardium. Metoprolol in some cases can successfully mask certain diseases, such as tachycardia. Therefore, it is very important to take the drug only under the close supervision of an experienced physician. In such cases, even abrupt withdrawal of the drug can only bode well for trouble. For heart failure, patients should receive the main course of treatment either before or after the substance is used. At the same time, such drugs cannot be combined. The main component is successfully metabolized in the liver, forming three important metabolites that do not have a blocking function. Almost all of the drug is excreted in the urine. Cleansing the body from the drug takes three to nine hours. A small amount of lactose in the composition does not allow patients with such intolerance to use the medicine.

Pregnancy and lactation

Since there are not enough clinical studies at the moment, it is not recommended for pregnant women, regardless of the trimester, to take Metoprolol. There is still no precise evidence that the medicine can have a negative effect on the fetus, but there is also no refutation of this fact. During lactation, women are better off replacing the remedy with a similar one that is permitted. When conducting experiments on animals, scientists have proven that the components penetrate into milk, thus getting into the child's body.

Childhood use

Metoprolol is prohibited for children and adolescents under the age of eighteen. In the case of a confirmed diagnosis, children are prescribed medications that are similar in action, but different in the main and auxiliary composition.

With impaired renal function

In patients with abnormal kidney function, the drug is excreted a little longer than usual. However, the resulting metabolites are also not beta blockers. Patients with a fixed diagnosis are allowed to take Metoprolol, but throughout the course, the patient must be under the close supervision of a doctor. If the condition worsens, dosage adjustment may be necessary.

For violations of liver function

Since the main active ingredient is excreted by the liver, dosage adjustment is sometimes required. It is better to start the course of treatment with a lower dose, gradually increasing it to the required milligrams. If the patient's condition has deteriorated sharply, the patient must go to the hospital without fail. Further treatment should be continued only at the discretion of the doctor.

Use in the elderly

For people over 65 years of age, no additional dosage adjustment is required. The attending physician may only reduce the daily dose if there are compelling reasons or individual concerns. Elderly patients take the medicine according to the traditional scheme, on an equal basis with other patients.

Terms and conditions of storage

It is advisable to store it in its original packaging. The air temperature should not exceed 25 degrees Celsius with moderate humidity in the room. Keep the drug in a dark place out of direct sunlight. The date of manufacture and the deadline for sale are mandatory indicated on each cardboard box. After five years from the date of release, the drug is not allowed to be taken internally.

Testimonials

Almost everyone in need can buy Metoprolol, because its price belongs to the budget line. According to numerous reviews, the drug of the German brand successfully combined low cost and excellent therapeutic qualities. A democratic analogue of expensive drugs effectively copes with the task assigned to it. However, the course of treatment should be prescribed only by a qualified medical professional, because the remedy, like any other, has several contraindications, which should be carefully looked at.

Terms of sell

A prescription is not required to buy Metoprolol.