Enzix Duo Forte tabs 20mg/2.5mg #30 + #15

Enzix Duo Forte user manual

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Medicinal composition and form

Enzix Duo Forte is presented in two different types of film-coated tablets:
    larger pills, which are part of enalapril in an amount of 0.02 g.
    small tablets containing indapamide at a concentration of 2.5 mg.
Excipients, including lactose, do not affect the pharmacological activity.
Each container contains 10 large enalapril tablets and 5 small indapamine pills. Each carton pack contains 3 currencies, together with the manufacturer's approved instructions for use.

Pharmacological possibilities

The specific effect of Enzix Duo Forte is achieved due to the combined effect of each of the active substances on the body.
The antihypertensive effect of enalapril is due to the suppression of the angiotensin-converting enzyme. This effect is carried out by enalaprilat, which is the result of the metabolism of enalapril. Inhibition of ACE leads to a decrease in the activity of the renin-angiotensin-aldosterone system and a decrease in pressure without an increase in heart rate.
The therapeutic effect of indapamide is carried out in several ways:
    decreased sensitivity of blood vessels to norepinephrine;
    an increase in vascular lumen, due to the activation of the secretion of prostaglandins;
    increased exposure to vasodilators (bradykinin);
The combination of effects makes the agent more effective in the treatment of sustained increases in blood pressure.

Indications for use

Taking Enzix Duo Forte is necessary for the treatment of arterial hypertension.
Application is possible after the instructions of a specialist and in the presence of a medical prescription.

Method of administration and dosage

To achieve a hypertensive effect, the dose of Enzix Duo Forte is a couple of tablets (one enalapril and one indapamide). Both pills are taken in the morning, with persistent hypertension, it is possible to take enalapril twice.
The maximum permitted daily amount of enalapril and indapamide is 40 and 2.5 mg, respectively.

Contraindications

Medical contraindications for the use of Enzix Duo Forte is the presence of hypersensitivity to the constituent components of the drug or diseases:
    porphyria;
    hypokalemia;
    anuria;
    kidney failure;
    connective tissue pathologies;
    cerebral circulation disorders.
Medical supervision is necessary when used by patients with:
    diabetes mellitus;
    primary hyperaldosteronism;
    renal artery stenosis;
    aortic and mitral stenosis;
    liver failure.

Side effects

Undesirable effects when using enalapril are expressed:
    Sleep disorders, headaches, nervousness, depression;
    Bronchospasm, shortness of breath, interstitial pneumonitis, pharyngitis;
    Noise in the ears, visual, auditory, coordination disorders;
    Dyspeptic disorders, pancreatitis, hepatitis, intestinal obstruction;
    Excessive decrease in blood pressure, orthostatic collapse, chest pain, myocardial infarction;
    Skin and allergic manifestations of immune reactions;
    Renal failure, proteinuria;
    Sexual dysfunction.
Side effects caused by indapamide can manifest themselves:
    Dyspeptic disorders;
    Asthenia, nervousness, depression, anxiety;
    Pharyngitis accompanied by a dry cough;
    Orthostatic hypotension;
    Increased risk of developing urinary tract infections, frequency of night urination;
    Rash, itching.

Overdose

When the therapeutic dose of enalapril is exceeded, excessive hypotension is noted, leading to pathologies of the blood supply to the brain, ischemic infarction of the heart muscle, collapse, convulsions, stupor.
A significant increase in the dosage of indapamide can cause dyspeptic disorders, depression of respiratory functions, drowsiness, lethargy, dizziness, and impaired consciousness.

Pregnancy and lactation period, childhood

Enzix Duo Forte is prohibited from taking when carrying a child and during lactation. If you need to use the medication, you should stop breastfeeding.

Drug interactions

When used in parallel with enalapril tablets, other antihypertensive drugs, diuretics, tricyclic antidepressants, antipsychotics, some anesthetics, alcoholic beverages and drugs based on ethyl alcohol, the hypotensive effect is enhanced.
NSAIDs and sympathomimetics reduce the pharmacological activity of enalapril.
In combination with antidiabetic agents, there is a pronounced drop in the amount of sugar in the blood.
Parallel therapy with lithium and gold preparations can cause toxic damage to the body due to an increase in their plasma concentration.
Use with angiotensin II receptor antagonists for the purpose of double blockade should be carried out under exceptional indications, strictly under the supervision of doctors.
Indapamide should not be combined with lithium-containing drugs, class I-a and III antiarrhythmic drugs, phenothiazines, butyrophenones, benzamides and some other agents (cisapride, pentamidine, halofantrine). Simultaneous use should be carried out under strict medical supervision.
NSAIDs, corticosteroid medications, tetracosactide reduce the therapeutic properties and increase the likelihood of acute forms of renal failure.
With the combined use of corticoid drugs (gluco- and mineral-), intravenous amphotericin B, tetracosactide, laxatives that increase peristalsis, cardiac glycosides, control and maintain the stability of potassium in serum.
Taking baclofen, an imipraminine-like antidepressant, can further lower blood pressure.
Cyclosporine, tacrolimus therapy can increase the amount of creatinine in the blood. With values ​​above 12 or 15 mg / l in female and male patients, respectively, treatment with metformin should be avoided.

Storage conditions

The instruction warns of the need to restrict children's access to the product, as well as the need to store Enzix Duo Forte in dry places, in a temperature range of 15-25 ° C.

Terms of sell

You can buy Enzix Duo Forte without a prescription from a doctor.