Enap-HL tabs 20mg/12.5mg #20

User manual for Enap-HL

You can buy Enap-HL here

Composition and release form

The main active components of Enap-HL:
    enalapril maleate 10 mg;
    hydrochlorothiziad 12.5 mg.
Associated substances: sodium bicarbonate, lactose monohydrate, calcium hydrogen phosphate, magnesium stearate, corn starch, talc.
The drug is marketed as flat, rounded, scored tablets. There are 10 tablets in a blister. One carton contains two blisters.

Pharmacological properties of Enap-HL

Enalaprinil blocks the conversion of the hormone angiotensin I to angiotensin II. The result is an increase in the level of angiotensin II, which has a pronounced vasoconstrictor effect. Narrowing of the lumen of blood vessels is the main cause of high blood pressure. The ACE enzyme reduces the level of angiotensin II, inhibits the breakdown of bradykinin, the antigen of angiotensin II. Enalaprinil reduces the concentration of aldosterone in the bloodstream, improves the work of the kallikrein-kinin vasodepressive system, which helps to maintain blood pressure within the normal range.
Hydrochlorothiazide is a medium-strength diuretic that slows down the return of fluid, chlorine, bicarbonate in the kidneys, and stimulates their excretion in the urine. As a result, the sodium content in the tissues and the susceptibility to vasoconstrictor factors decrease. This can significantly reduce the load on the organs of the cardiovascular system.
Enalapril causes retention of potassium in the blood, while hydrochlorothiazide lowers its levels. The combination of these two substances helps maintain the balance of potassium in the bloodstream.

Indications for use

The basis for the indication of the drug is arterial hypertension.

Contraindications

The instruction contains a list of factors in which the appointment of a combined agent is prohibited. It:
    Addison's disease;
    renal failure;
    angioedema of an idiopathic or hereditary nature;
    previously occurred angioedema, which occurred as a result of the use of ACE inhibitors;
    hypersensitivity to sulfonamides;
    an allergic reaction to the constituent components;
    diabetes;
    pregnancy and breastfeeding;
    age less than 18 years.
Reception of Enap-HL has no contraindications, but is limited for patients with the following diseases:
    severe aortic stenosis;
    renal or hepatic dysfunction;
    autoimmune disease;
    increased potassium in the blood;
    gout.
Seniors over 60 are also in the special attention group.

Method and features of reception

The dosage of Enap-HL is determined by the attending physician after the examination. Independent actions can lead to negative consequences. The instructions for use indicate that the reception is carried out once, 1 tablet each. It should be drunk in the morning, with or after meals, with plenty of fluids.
If the course of treatment is at an early stage, then a lower dose may be indicated. With a positive reaction and general well-being, a standard dosage is possible.
If you miss a tablet, you cannot take two at a time. In the interval of more than 12 hours, reception is allowed, less than 12 hours - no. The active ingredients of the drug are stored in blood plasma in sufficient concentration during the day. The duration of the therapeutic course is determined by the attending physician; there are no time limits.
Alcohol is able to enhance the hypotensive function of Enap-HL, therefore, it is not recommended to take alcoholic beverages together with the medicine.

Side effects of Enap-HL

The medication can cause a negative reaction from:
    Cardiovascular system: a sharp jump in blood pressure, palpitations, arrhythmia, stroke, heart attack.
    Respiratory system: rhythm, bronchospasm, embolism, pneumonia, rhinitis;
    CNS: irritability, sleep disturbance, depression;
    Gastrointestinal tract: nausea, vomiting, diarrhea, hepatitis, jaundice;
    Genitourinary system: renal impairment, failure, nephritis;
    Others: sexual weakness, eye diseases, rash.

Overdose

If symptoms such as increased diuresis, a sharp drop in blood pressure with other heart disorders, convulsions occur, you should immediately seek medical help. In severe cases, paresis, paralytic ileus, loss of consciousness, coma may occur.
Treatment is carried out as follows: the patient is placed in a prone position with a low headboard. Sometimes gastric lavage is required. All this time, blood pressure is monitored in order to stabilize the condition.

Interaction

The simultaneous administration of Enap-HL with antihypertensive drugs, barbiturates, narcotic substances, tricyclic antidepressants enhances the effect of the drug. NSAIDs and analgesics reduce the effect of its use. Lithium agents are not recommended, intoxication may develop.

Storage conditions

The shelf life is 2 years. Keep out of the reach of children.

Terms of sell

You can buy Enap-HL without a prescription.