Enam tabs 10mg #20

Instruction for Enam

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Enam is an antihypertensive drug.

Composition and form of release

The drug is available in tablet form at a dosage of 2.5 mg, 5 mg and 10 mg. The active substance of the drug is enalapril maleate.
In blister strip packs of 10 tablets. 20 tablets in a carton box (two packs each).

Pharmachologic effect

According to the instructions, the drug is an antihypertensive drug. The active ingredient is rapidly absorbed into the body, forming a pharmacologically active substance - enalaprilat. The use of the drug inhibits the angiotensin-converting enzyme in the body, preventing the conversion of angiotensin I into angiotensin II, which helps to reduce the total peripheral vascular resistance, reduces the level of aldosterone and increases the level of bradykinin, activates depressive systems and inhibits pressor systems.
Reception of the drug according to indications leads to a decrease in diastolic and systolic pressure, without developing reflex tachycardia.
According to reviews, the drug reduces left ventricular hypertrophy and reduces myocardial oxygen demand. In conditions of hypoxia, it improves the condition of the heart muscle. The drug prevents the development of diabetic nephropathy, increases renal blood flow, which leads to a decrease in cardiac mortality. Enam has no effect on carbohydrate and lipid metabolism.

Indications

According to the instructions, Enam is prescribed for the treatment of patients suffering from arterial hypertension in various forms, including essential arterial and renovascular hypertension.
In addition, the indication for Enam is chronic heart failure (as part of a combination therapy).
The drug is used to prevent coronary ischemia and severe heart failure in patients with reduced left ventricular function.

Method of application and dosage regimen

According to the instructions, Enam is intended for oral administration. The drug is taken regardless of food intake, as a rule, once a day at approximately the same time. The dosage of the drug depends on the age of the patient and the indication for Enam.
With essential hypertension in adults, as a rule, the dosage is 2.5-5 mg per day. The maximum dosage of the drug is 40 mg per day.
Before taking enalapril, it is recommended that patients taking diuretics stop taking them at least three days in advance. Enam therapy is started with the minimum dosage, gradually increasing it to the optimal one.
With heart failure in adults, the initial dosage is 2.5 mg per day, with a gradual increase to 20 mg.
With reduced renal function, the dosage of enalapril needs constant correction. The maximum daily dosage for people with reduced creatinine clearance from 30 to 80 ml / min is 10 mg, and with creatinine clearance from 10 to 30 ml / min - 5 mg. For patients on hemodialysis, the maximum daily dosage is 2.5 mg.
The intervals between dosage increases should be at least two weeks.
For children over six years of age with arterial hypertension, the initial dosage of Enam is 2.5 mg per day. The maximum daily dosage for children is calculated on the basis of 0.58 mg per kg of body weight.

Contraindications

The instructions for Enam indicate the following contraindications:
    hypersensitivity to enalapril and other components of the drug;
    aortic and mitral stenosis;
    the period of pregnancy and breastfeeding;
    reduced renal function (creatinine clearance less than 30 ml / min);
    idiopathic or hereditary angioedema;
According to reviews, Enam is not recommended for patients with glucose-galactose malabsorption syndrome, galactosemia and lactase deficiency, since the drug contains lactose.
The drug is prescribed with caution when:
    hypovolemia;
    violation of cerebral blood flow;
    ischemic heart disease;
    violation of the water-salt balance;
    heart failure;
    decreased kidney function;
    renal artery stenosis.

Side effects

According to reviews, the drug is mostly well tolerated by patients. At the very beginning of treatment, a slight decrease in blood pressure, increased fatigue and dizziness are possible. In addition, the drug can cause the following side effects:
    Respiratory system: rhinorrhea, pharyngitis, glossitis, shortness of breath, unproductive cough. If a cough occurs, it is recommended to stop taking enalapril and prescribe an alternative therapy.
    Cardiovascular system: bradycardia, myocardial infarction, angina pectoris, tachycardia.
    Gastrointestinal tract: indigestion and stool, nausea, dryness of the oral mucosa, pancreatitis, pain in the epigastric region, increased activity of hepatic transaminases, decreased liver function. In addition, according to reviews, Enam can cause stomatitis, intestinal obstruction, decreased appetite and a change in taste.
    Central nervous system: depression, headache, seizures, insomnia, impaired coordination of movements, tinnitus, paresthesia.
    Hematopoietic system: hypoglycemia, neutropenia, a decrease in the level of leukocytes, hematocrit and hemoglobin, proteinuria, an increase in the concentration of bilirubin and potassium in the blood plasma.
    Allergies: bronchospasm, urticaria, pruritus. Rarely, angioedema of the face, lips and tongue, larynx may occur. In this case, urgent help is required.
    Other side effects: agranulocytosis, erectile dysfunction, alopecia, Raynaud's syndrome, hot flashes, renal failure, excessive sweating.
In addition to the above symptoms, the use of the drug can cause the development of a sympathocomplex, which includes: vasculitis, hyperemia, pain in joints and muscles, eosinophilia, leukocytosis, an increase in the erythrocyte sedimentation rate and the presence of antinuclear bodies in the body.

Application of the drug Enam during pregnancy and breastfeeding

The drug is contraindicated during pregnancy. Before starting therapy with enalapril, it is recommended to exclude the likelihood of pregnancy, and while taking it, use reliable contraception. If pregnancy does occur, you must stop taking Enam.
When using the drug during lactation, the issue of stopping breastfeeding should be resolved.

Overdose

According to reviews, Enam in too high dosages leads to arterial hypotension.
In case of an overdose, it is necessary to perform a gastric lavage and carry out symptomatic treatment.

Storage conditions

The drug is stored in a dry place at room temperature for no longer than 36 months.

Terms of sell

A prescription is not required to buy Enam.