Cardosal Plus tabs 12.5mg + 20mg #28


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Cardosal Plus user manual

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Pharmacological effect

The drug has a therapeutic effect due to the hypotensive properties of the components. The use of the medication causes persistent and long-term effects. Hydrochlorothiazide has a diuretic effect. Removing excess fluid from the vascular bed allows you to reduce the pressure in them. The diuretic effect is achieved by reducing sodium reabsorption in the renal tubules. The substance blocks the work of the enzyme carbonic anhydrase and accelerates the excretion of potassium by the kidneys. Olmesartan medoxomil belongs to the group of angiotensin II receptor antagonists. Angiotensin II is involved in the complex mechanism of the renin-angiotensin-aldosterone system. By inhibiting its properties, the substance interrupts the chain of activation of hormones that retain fluid in the body and lead to the development of arterial hypertension. The combination of a thiazide diuretic and an angiotensin II receptor antagonist is the ideal solution to combat high blood pressure. The hypotensive effect after using the minimum concentration of the drug lasts for 24 hours. The drug does not have a withdrawal syndrome and no rebound increase in blood pressure is observed when the drug is discontinued.

Composition of the preparation

In addition to auxiliary ingredients, the combined product Cardosal Plus includes two active ingredients: hydrochlorothiazide and olmesartan medoxomil. The drug is taken orally and is available in pill form.

Indications for use

The indication for the use of Cardosal Plus tablets is an increase in blood pressure. The agent is prescribed for monotherapy of hypertension and for the complex treatment of diseases accompanied by hypertension.

Side effects

Side effects can occur if the instructions for the use of Cardosal Plus tablets are violated. Undesirable effects are manifested in the form of dizziness, hypotension, allergies, and abdominal pain. Hydrochlorothiazide can cause dehydration phenomena, lead to a decrease in circulating blood volume and disrupt electrolyte metabolism. Contraindications include severe disorders in the functioning of the kidneys and liver, sensitivity to components, the period of breastfeeding and pregnancy. Reception is not recommended for persons suffering from diabetes mellitus and lactose intolerance.

Pregnancy and lactation

The use of a medication can cause teratogenic effects on the fetus, therefore, the period of bearing a child is an absolute contraindication. The components of the agent are able to suppress lactation and penetrate into breast milk, it is recommended to stop breastfeeding during therapy.


Before taking the Cardosal Plus complex, you must consult a doctor who determines the dose and duration of the course of therapy. It is recommended to take 1 tablet daily. The maximum concentration should not exceed 25 milligrams of hydrochlorothiazide and 20 milligrams of olmesartan medoxomil per day.

Features of reception

It is necessary to observe a moderate dosage of the drug Cardosal Plus to prevent unwanted manifestations. It is recommended to control the level of potassium in the blood, since the components of the drug affect the exchange of electrolytes. It is necessary to control the intake of the drug by patients suffering from coronary heart disease, since persistent hypotension can lead to myocardial infarction.

Alcohol compatibility

It is not recommended to consume alcoholic beverages during antihypertensive therapy. Alcohol dilates blood vessels and can lead to hypotension.

Interaction with other medications

Cardosal Plus should not be taken with potassium-sparing diuretics and potassium-containing preparations, as this can lead to hyperkalemia. In combination with NSAIDs, they lead to impaired filtration processes and renal failure. When taken together with methyldopa, there is a risk of anemia.


With increasing dosage, persistent hypotension and dehydration of the body may occur. This, in turn, can lead to irreversible consequences. Therapeutic measures include detoxification, intake of sorbents and gastric lavage.

Reviews of patients and doctors

Cardosal Plus is often prescribed by family doctors for the complex therapy of hypertension. The multi-component nature of the drug allows you to eliminate the manifestations of the disease for a long time. Patients taking the product emphasize the effectiveness and availability of the product. The presence of active ingredients belonging to various pharmacological groups in it saves money and time when taking pills.

Storage rules

It is recommended to store the medicinal product in a dry place out of the reach of children, at a temperature not exceeding 30 degrees. Suitable for use three years from the date of issue.

Terms of sell

You can buy Cardosal Plus without a prescription from a doctor.