Diflucan caps 150mg #4

Instruction for Diflucan

You can buy Diflucan here

It is usually well tolerated and used not only for treatment, but also as a prophylactic agent for the prevention of fungal infections. Its popularity is associated with a large selection of dosage forms that facilitate the use of the drug in different age groups.

Release form and composition

Release form and storage conditions
    Capsules of 50 and 100 mg are 7 pieces in a blister of foil. 1 or 4 blisters are placed in a cardboard box.
    150 mg capsules are also packaged in a blister of 1 or 4 pieces. In a cardboard pack there is 1 blister.
    Diflucan suspension powder 50 mg per 1 ml or 100 mg per 1 ml. The powder is packaged in plastic bottles with a lid protected from children. In a carton box there is 1 such bottle and a measuring spoon.
    The solution for intravenous administration Diflucan is poured into transparent bottles of light glass of 25, 50, 100 and 200 ml. The bottle is closed with a rubber stopper and compressed with an aluminum cap and has a plastic holder. Located in a carton box.
The composition means in the form of capsules
    1 capsule contains the main active ingredient fluconazole in the amount of 50, 100 and 150 mg,
    as well as auxiliary components lactose, corn starch, colloidal silicon dioxide, magnesium stearate, sodium lauryl sulfate. The capsule shell contains titanium dioxide, gelatin and a dye.
The composition of the solution Diflucan
    1 ampoule of solution for injection contains 2 mg of the main active ingredient fluconazole,
    as well as auxiliary components, including sodium chloride and purified water.

Pharmacological effect

Diflucan belongs to the group of antifungal agents and is very effective against many types of mycoses. The drug destroys yeast-like fungi, mold fungi, dermatophytes, as well as dimorphic forms of pathogens.
    Inside the body, the active substance Diflucan - fluconazole is rapidly absorbed through the mucous membranes of the digestive tract into the systemic circulation, the maximum concentration of the drug in the blood is observed already 1-1.5 hours after taking or administering the drug. The effect persists for 24-30 hours, which makes it possible to take the medicine once a day.
It penetrates well into all biological fluids: saliva, sputum, vaginal and penis secretions, cerebrospinal fluid, blood, plasma, semen, and others. In addition, the silent part of the drug accumulates in the stratum corneum of the skin, which makes it even more effective.

Indications for use

Instructions for use of Diflucan contains the following indications for the use of a medicinal substance:
    Deep endemic mycoses.
    Candidiasis mucous. This category includes mucous membranes of the pharynx, esophagus, mouth.
    Genital and vaginal candidiasis. Diflucan for thrush in women is also used to prevent illness in the event of more than 3 exacerbations per year.
    Cryptococcosis. This category includes cryptococcal meningitis, as well as infections of other localization - for example, lungs or skin.
    Generalized form of candidiasis. This group includes disseminated candidiasis, candidemia, and other types of invasive infections.
    Mycoses of the skin. The drug is used for fungal infections of the feet, groin area, body. The indications include pityriasis versicolor, skin infections and onychomycosis.

Contraindications for Diflucan

    Simultaneous administration of cisapride;
    Breastfeeding period;
    The simultaneous use of terfenadine on the background of repeated use of fluconazole at a dose of 400 mg per day and above;
    Hypersensitivity to the components of the drug and azole substances with a structure similar to fluconazole.
It is necessary to avoid the use of the drug during pregnancy, with the exception of severe forms of fungal diseases that threaten the life of the mother, when the likely benefit of treatment outweighs the possible risk to the fetus.

Use during pregnancy and lactation

The drug is undesirable to use during pregnancy and lactation, as there is no information about the safety of its use in these categories of patients.
For pregnant women, Diflucan can be prescribed by the attending physician solely for health reasons, and to lactating patients - on condition of a temporary cessation of breastfeeding.

Instructions for use

The instructions for use indicate that the choice of dosage form, the dose of Diflucan and the period of treatment depend on the patient’s clinical condition and laboratory data, therefore, they are determined by the doctor individually.
Capsules should be swallowed whole. The recommended dosage of Diflucan for adult patients:
    For vaginal candidiasis (thrush), balanitis, the drug is taken orally once in a dose of 150 mg. In order to reduce the frequency of recurrences of vaginal candidiasis, the use of Diflucan at a dose of 150 mg once a month for 4-12 months is indicated.
    In case of mucosal candidiasis, Diflucan is indicated in a dose of 50-100 mg per day for 0.5-1 months. Patients with AIDS to prevent recurrence of oropharyngeal candidiasis prescribe the drug at a dose of 150 mg per week.
    For disseminated candidiasis, candidaemia and other invasive candidiasis, a dose of 400 mg is administered on the first day, and subsequently treatment is continued at 200 mg per day. The duration of the drug depends on the clinical efficacy.
    For cryptococcal infections, including cryptococcal meningitis, patients take 400 mg of Diflucan on the first day, and subsequently the treatment is continued at a dose of 200-400 mg per day. The duration of therapy lasts on average 1.5-2 months. Patients with AIDS to prevent the recurrence of cryptococcal meningitis drug is prescribed at a dose of 200 mg per day for a long time.
    With oropharyngeal candidiasis, the drug is indicated in a dose of 50-100 mg per day for 1-2 weeks. In case of atrophic candidiasis caused by wearing dentures, the medicine is taken 50 mg per day for 2 weeks in combination with local preparations for the treatment of the prosthesis.
    In case of mycoses, the drug is taken at a dose of 150 mg per week or 50 mg per day for 2-4 weeks; pityriasis lichen - 300 mg per week for 2 weeks; Onychomycosis - 150 mg 1 time per week until the replacement of an infected nail; deep endemic mycoses - 200-400 mg per day for up to 2 years.
    Patients undergoing chemotherapy and radiotherapy fluconazole administered in the dose of 50-400 mg per day. The duration of the drug use is determined individually by the attending physician.
For the treatment of mucosal candidiasis, children are given a dose of 6 mg per kg of body weight on the first day, after which it is reduced to 3 mg per kg of body weight per day. In generalized candidiasis and cryptococcal infections, the dosage ranges from 6 to 12 mg per kg of body weight per day and depends on the severity of the disease.
For the prevention of fungal infections in children with reduced immunity after radiation or chemotherapy, it is prescribed from 3 to 12 mg per kg of body weight, depending on the severity of neutropenia.
In newborns, fluconazole is eliminated more slowly than in older children, so in the first 2 weeks of life the child is given in the usual infant dosage, but with an interval of 72 hours. For babies of 3-4 weeks of age, the same dosage is administered at intervals of 48 hours.

Side effects of Diflucan

    Violations of the skin (alopecia, allergic skin diseases);
    Violations of the cardiovascular system (violation of electrocardiogram performance);
    Various allergic reactions (anaphylactic shock, skin rashes, angioedema, urticaria, pruritus);
    Nervous system disorders (convulsive syndrome, headaches, changes in taste perception, dizziness);
    Disturbances of metabolic processes (decrease in the level of potassium ions, increase in the level of cholesterol, increase in the level of triglycerides);
    Disorders of the hematopoietic system (decrease in the number of leukocytes, decrease in the number of platelets, decrease in the number of neutrophils, increase in the number of agranulocytes);
    Disorders of the digestive system (functional disorders of the liver, disorders of the chair, nausea, disorders of the organs, jaundice, liver poisoning (including death), vomiting, increased levels of liver enzymes, flatulence, liver necrosis, increased bilirubin, abdominal pain, increased aminotransferase).

Overdose

In cases of overdose, psychomotor reactions may develop. Therapy is to accelerate the excretion of the drug from the patient's body, by washing the stomach and using enterosorbents. Hemodialysis in this case is also effective.
Upon completion of these procedures, the patient is prescribed symptomatic therapy.

special instructions

    As with other azoles, fluconazole in rare cases can cause anaphylactic reactions.
    The simultaneous use of fluconazole in doses of less than 400 mg / day and terfenadine should be carried out under close supervision.
    Evidence for the efficacy of fluconazole in the treatment of other types of endemic mycoses, such as paracoccidioidomycosis, sporotrichosis, and histoplasmosis is limited, which does not allow us to determine specific recommendations for dosing.
    There have been reports of cases of superinfection caused by Candida strains other than Candida albicans, which often have natural resistance to fluconazole (for example, Candida krusei). In such cases, alternative antifungal therapy may be required.
    Like other azoles, fluconazole can cause an increase in the QT interval on the ECG. With the use of fluconazole, an increase in the QT interval and ventricular flicker / flutter were very rarely observed in patients with multiple risk factors, such as organic heart disease, electrolyte imbalance, and concomitant therapy promoting the development of such disorders. Therefore, in such patients with potentially proarrhythmic conditions, fluconazole should be used with caution.
    During treatment with fluconazole, patients rarely developed exfoliative skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis. AIDS patients are more likely to develop severe skin reactions with the use of many drugs. When a rash appears in a patient receiving treatment for a superficial fungal infection, which can be associated with the use of fluconazole, the drug should be discontinued. When a rash appears in patients with invasive / systemic fungal infections, they should be carefully monitored and fluconazole should be canceled when there is a bullous lesion or erythema multiforme.
    In rare cases, the use of fluconazole was accompanied by toxic changes in the liver, including fatal, mainly in patients with serious comorbidities. There is no marked dependence of the hepatotoxic effects of fluconazole on the total daily dose, duration of therapy, sex and age of the patient. The hepatotoxic effect of fluconazole has usually been reversible; his symptoms disappeared after cessation of therapy. It is necessary to observe patients in whom indicators of liver function are impaired during treatment with fluconazole, in order to identify signs of more serious liver damage. If clinical signs or symptoms of liver damage appear that may be associated with fluconazole, the drug should be withdrawn.
Patients with diseases of the liver, heart and kidneys are advised to consult a doctor before using the drug. When using Diflucan 150 mg for vaginal candidiasis, patients should be warned that symptom improvement is usually observed after 24 hours, but sometimes it takes several days to completely disappear. If symptoms persist for several days, you should consult a doctor.

Drug interactions

During treatment, it should be noted that Diflucan does not fit well with all medical products. Clinical studies have shown that:
    simultaneous use with Diazepam or similar agents may result in psychomotor reactions;
    when used with cisapride and terfenadine, a change in heart rate and the development of arrhythmia may occur;
    simultaneous reception of fluconazole with coumarin group anticoagulants may be accompanied by bleeding;
    with the appointment of additional treatment with hydrochlorothiazide, there is an increased concentration of the active substances Diflucan in the blood plasma.

Reviews

We picked up some reviews of people on the drug Diflucan:
Svetlana
    Quickly copes with thrush, literally two pills were enough to stop the burning sensation and strong discharge. After the vigilant Livarola in the candles, the problem of thrush returned all the time, and after Diflucan okay, almost half a year! The only negative - a couple of days hurt the stomach after the pills, but you can suffer.
Galina
    The fact that one capsule treats thrush is a myth, it simply removes the symptoms. At the first opportunity there will be a relapse, and so on to infinity. At a minimum, it is necessary to drink a week, and even with local combination products like metrogil plus, and even with probiotics. Then you can still hope for a cure.
Lena
    The last exacerbation of thrush happened to me about three months ago, I went to a pharmacy, the pharmacist recommended taking zalain candles, said that one application should be used and there will be a much more lasting effect. Doubt caused only the high cost of the drug, but I still took it))) I put in a candle for the night. In the morning I saw a completely different quality of discharge on the gasket - these were no longer cheesy flakes, but more like mucus. Itching went completely on the third day.
Olga
    I got a fungus on my legs after visiting the pool. By that time, I had just finished a course of antibiotics, so the immunity was weaker than ever. I was surprised when the doctor prescribed Diflucan, because she thought that they only treated thrush. He was treated for more than a month, everything went away. True, she suffered from insomnia, which disappeared after stopping treatment.

Storage conditions

Diflucan should be stored in a dry place inaccessible to children. Allowable temperature for all forms of the drug - about 30 degrees.
The recommended shelf life of Diflucan is not more than 5 years.

Terms of sell

You don't need a prescription to buy Diflucan.