Biseptol tabs 480mg #28

Instruction for Biseptol

You can buy Biseptol here

Release form and composition

A substance that provides Biseptol therapeutic effect, called co-trimoxazole. This name combines two active compounds, the ratio of which in one tablet is 5 to 1. Depending on the number of such active substances, the drug is presented in two dosages:
    120 mg tablets containing 100 mg of sulfamethoxazole, supplemented with 20 mg of trimethoprim.
    480 mg tablets, of which the patient receives sulfamethoxazole in an amount of 400 mg, and trimethoprim in a dose of 80 mg.
Biseptol tablets are distinguished by a round flat shape, white (sometimes with yellow) color, and the presence of risks and Bs engraving. They are packaged in blisters of 20 pieces and sold for 1 blister in a pack.

Pharmacological effect

"Biseptol" (480, 120, and 240 mg) is a broad-spectrum antimicrobial drug that refers to sulfanilamide drugs. The combination of active substances prevents the synthesis of folic acid, which is responsible for metabolic processes in microbial cells, as well as their division.
    Co-trimoxazole does not kill the causative agents of various diseases, but restricts their reproduction, giving the immune system the ability to cope with pathogens on its own. This explains the absence of a strong toxic effect during Biseptol treatment.
The drug is able to cope with about 40 types of pathogenic microorganisms, including streptococcal and staphylococcal infections, Vibrio cholerae, Toxoplasma, Salmonella, Chlamydia, E. coli and others. Anaerobic and mycobacteria, as well as viruses, the drug has no effect.
It is also used for the primary and secondary prevention of pneumocystosis and toxoplasmosis in HIV carriers.

Indications for use

According to the manufacturer’s instructions, Biseptol is prescribed for the treatment of infectious and inflammatory diseases, which are caused by microorganisms sensitive to the drug, namely:
    Gonorrhea;
    Otitis, sinusitis;
    Infections of soft tissues and skin, including pyoderma, furunculosis;
    Infections of the urogenital system, including urethritis, pyelonephritis, prostatitis, salpingitis;
    Various respiratory tract infections, including pneumonia, bronchitis, lung abscess, pleural empyema;
    Infections of the gastrointestinal tract, including abdominal paratyphoid fever, typhoid, bacterial cholera, dysentery, diarrhea.

Biseptol - antibiotic or not?

According to the abstract, Biseptol is not an antibiotic. It is a bactericidal drug (it causes the death of a microbial cell), but it does not apply to antibiotics. The action of the drug due to the fact that it blocks the synthesis of folic acid, without which the microbial cell can not divide. Sulfamethoxazole and trimethoprim complement and reinforce each other in this mechanism.

Contraindications

Absolute contraindications:
    severe renal dysfunction in the absence of the ability to control the concentration of the drug in the blood plasma;
    hyperbilirubinemia in children;
    severe blood diseases;
    deficiency of glucose-6-phosphate dehydrogenase;
    established damage to the liver parenchyma;
    severe renal failure;
    Hypersensitivity to the components of the drug, as well as to sulfonamides.
Biseptol should not be taken by women during pregnancy and lactation.
Children do not prescribe the drug:
    pills - up to 3 years;
    suspension - up to 2 months (or up to 1.5 months if the child was born from a mother with HIV infection).
Caution requires the use of Biseptol in the presence of the following diseases:
    bronchial asthma;
    lack of folic acid in the body;
    thyroid disease.

Use during pregnancy and lactation

In pregnancy, the drug should be prescribed only if the expected benefit from its use exceeds the possible risk to the fetus, since both trimethoprim and sulfamethoxazole penetrate the placental barrier and, thus, can affect folic acid metabolism. In late pregnancy, the use of the drug should be avoided due to the possible risk of nuclear jaundice in newborns.
Due to the fact that trimethoprim and sulfamethoxazole penetrate into breast milk, the use of co-trimaxosol during lactation is contraindicated.

Instructions for use

The instructions for use indicate that the dosage of Biseptol is set individually depending on the disease. The drug is taken after meals with a sufficient amount of liquid.
    Children aged 3 to 5 years, the drug is prescribed 240 mg (2 tab. 120 mg) 2 times / day; children aged 6 to 12 years old - 480 mg each (4 tablets of 120 mg or 1 tablet of 480 mg) 2 times / day.
    Adults and children over 12 years old are prescribed 960 mg 2 times / day, with long-term therapy, 480 mg 2 times / day.
    Duration of treatment is from 5 to 14 days. In severe cases of the disease and / or in chronic infections, a single dose may increase by 30-50%.
With the duration of the course of therapy for more than 5 days and / or increasing the dose of the drug, it is necessary to monitor the peripheral blood picture; when pathological changes occur, folic acid should be administered at a dose of 5-10 mg / day.
    In pneumonia, the drug is prescribed at the rate of 100 mg of sulfamethoxazole per 1 kg of body weight / day. The interval between doses is 6 hours, the duration of treatment is 14 days.
    In gonorrhea, the dose of the drug is 2 g (in terms of sulfamethoxazole) 2 times / day with an interval between doses of 12 hours.
In patients with renal insufficiency with a CC of 15-30 ml / min, the standard dose of Biseptol should be reduced by 50%.

Side effects

Patients may experience the following side effects when treating Biseptol:
    Urinary tract: tubulointerstitial nephritis, elevated creatinine, salt diathesis,
    Metabolism: Biseptol should be taken with caution in disorders of potassium metabolism;
    Gastrointestinal system: hepatitis, abnormal stool (diarrhea), cholestatic syndrome, glossitis, elevated levels of liver enzymes, in patients with severe chronic diseases and immune diseases, acute pancreatitis is often diagnosed;
    Skin reactions, which often disappear after drug withdrawal: an increase in the body's sensitivity to the effects of ultraviolet radiation, polymorphic erythema, malignant exudative erythema, acute or toxic epidermal necrolysis, hemorrhagic vasculitis;
    Central nervous system: meningeal syndrome, impaired motor coordination, hallucinatory conditions;
    Musculoskeletal system: muscle and joint pain;
    Changes in the blood picture: a decrease in the level of leukocytes in the general cellular composition of the blood, a decrease in the number of neutrophils, a low content of platelets, neutropenia, a deficiency of folic acid, aplastic anemia, an increase in the concentration of methemoglobin, Verlgof disease.
In patients with diabetes mellitus, in the first days of therapy there is a decrease in the concentration of glucose in the blood. Hypoglycemia also occurs in individuals with kidney and liver disease. The cause of this pathological condition may be inadequate nutrition.

Overdose

With a significant excess of the recommended therapeutic dose develop symptoms of acute poisoning - nausea, vomiting, abdominal pain, headache, impaired consciousness. In this case, the drug should be stopped and seek medical help.
Detoxification therapy includes gastric and intestinal lavage and symptomatic therapy. Chronic overdose can lead to depression of blood formation with a significant decrease in the number of all blood cells.

special instructions

Requires regular monitoring of the concentration of sulfamethoxazole in the blood. If the value is more than 150 µg / ml, the treatment is stopped until the value reaches 120 µg / ml and below. If the course of treatment is designed for a month or more, then regular monitoring of the blood condition is required.
With the appointment of folic acid, hematological changes are reversible. In AIDS patients, side effects are more common and are pronounced. Biseptol is not recommended to be prescribed for pharyngitis and tonsillitis caused by beta-hemolytic streptococcus gr. BUT.

Drug interactions

    Derivatives of salicylic acid increase the effect of Biseptol.
    Sulfamethoxazole and trimethoprim increase the anticoagulant activity of indirect anticoagulants, as well as the action of hypoglycemic drugs and methotrexate.
    In combination with thiazide diuretics, there is a risk of thrombocytopenia and bleeding.
    In combination with diuretics increases the risk of thrombocytopenia.
    Biseptol reduces the intensity of hepatic metabolism of phenytoin and warfarin, enhancing their action.
    Phenytoin, barbiturates, PAS increase the manifestations of folic acid deficiency in combination with Biseptol.
    Benzocaine, procainum, procainamide (as well as other drugs, as a result of the hydrolysis of which PABK is formed) reduce the effectiveness of the drug Biseptol.
    Ascorbic acid, hexamethylenetetramine increase the risk of crystalluria when taking Biseptol.
    Biseptol may increase the content of digoxin in the blood plasma in some elderly patients.
    In combination with drugs that inhibit bone marrow hematopoiesis, the risk of myelosuppression increases.
    Biseptol reduces the effectiveness of oral contraceptive drugs.

Reviews

We picked up some reviews of people about the drug Biseptol:
Olga
    I consider “Biseptol” an old, reliable, proven drug that helps in solving the problems of not only the sick respiratory organs, but also of ulcers, barley, and diarrhea. She treated herself and her children with success. I know that it is bad for the liver, because it consumed it only after eating and drinking milk. In a battle with broncho-pulmonary diseases, it is obligatory to take 4 tablets per day, 2 times with an equal interval within 3-5 days, depending on the severity. For ulcers, it is enough to take 1-2 tablets of 2 tablets a day, and it saves from diarrhea from one administration in the same number of tablets. Wonderful drug!
Tatyana
    That's right, if dogs are treated, that means a person will do. Biseptol is better to refrain from giving to children (under 8 years old) - boys. It acts on the testicles. This was told to me in 1982 by one of the very smart and competent therapists. And in the future it can be perfectly used in the treatment. Bronchitis was treated before without the use of antibiotics. And they did an excellent job. Now they are getting everyone on antibiotics. Immediately allergies, hormones and the process started.
Ruslan
    Antibiotics kill microorganisms, and antimicrobials are not directly deadly to them, but disrupt their metabolism, as a result of which they die. This drug, for example, disrupts the formation of folic and dihydrofolic acids among microorganisms. This favorably distinguishes the drugs of this group from antibiotics in that they do not destroy the useful microflora so much and have fewer side effects.
Irina
    This is a very good medicine. The older child often suffered from coughing during the cold season, the throat began to ache almost every 2-3 weeks. The treatment took quite a long time. These pills helped a lot. There are small tablets for children, but my child asked to crush them and take them as a powder. They are quite bitter, but the effect of them is excellent when coughing. I know that even acquaintances suffering from bronchitis speak very well about this drug. She herself took “Biseptol” for adults when coughing, also helped. Only here the size of the tablets for adults is very large.
Edwin
    I used to use Biseptol frequently, especially in the winter period, when I’m freezing, before going to bed two tablets and in the morning vigorous. But once I was jinxed by a kind doctor after the operation and now I get blobs and itchs. I haven't applied for 17 years, but I would like to return to him, doxycycline as a dead poultice.

Storage conditions

Biseptol refers to antibacterial drugs, leave from pharmacies which are allowed only for medical purposes. The shelf life of Biseptol tablets and Biseptol 480 when necessary storage conditions are met is 5 years, suspensions are 3 years.

Terms of sell

You can buy Biseptol without a prescription.