Amosin suspension 250mg 3gr #10

Instruction for Amosin

You can buy Amosin here

Amosin is a semi-synthetic drug from the group of penicillins of antibacterial broadly spectral action.
Its effect is manifested in the inhibition of the enzyme transpeptidase, in the violation of the stability of the cell walls, inhibition of the development of pathogenic microorganisms and their division at the cellular level, which ultimately causes lysis of the pathogenic microflora.

Release form and composition

Amosin powder for suspension for oral administration has a white color with a yellowish tint and a specific odor. The prepared suspension turns out white with a yellowish shade of color and a specific smell. Packed in single-dose packages of 1.5; 3 and 6
Amosin powder for suspension 1 pack.
Amoxicillin (in the form of trihydrate) 125, 250 or 500 mg
Excipients: polyvinylpyrrolidone (povidone), glucose (dextrose), Trilon B (disodium edetate), disodium phosphate disodium (sodium hydrogen phosphate), sodium α-glutamate monohydrate, food flavoring, vanillin, sucrose.

Pharmacological effect

The active component of the therapeutic agent actively affects gram-negative bacteria - Neisseria meningitidis and Listeria monocytogenes and Bacillus anthracis, Klebsiella spp., Neisseria gonorrhoeae and Helicobacter pylori; on gram-positive staphylococcal and streptococcal bacteria. Pathogenic microflora that produce penicillinase is immune to the effects of the active ingredient Amosin.
The effect of taking a therapeutic drug is manifested at 15-30 minutes and lasts for 8 hours. The drug is easily and for a short time absorbed by the walls of the gastrointestinal tract, and the presence of food in it does not affect the speed of absorption. The maximum content of amoxicillin is achieved in the blood plasma in the first 1-2 hours. The bloodstream brings the active component of the drug to the mucous membranes of the organs, bone and connective tissue, intraocular sputum and fluid. The time of removal of funds through the kidneys averages from two to three hours and may increase in patients with impaired renal function.

Indications for use

Antibiotic Amosin prescribed for bacterial infections:
    Urogenital infections (cystitis, pyelonephritis, urethritis, pyelitis, gonorrhea);
    Infectious diseases of the digestive tract (dysentery, abdominal type, salmonellosis, cholecystitis);
    Borreliosis;
    Meningitis;
    Acute infectious diseases of the upper respiratory tract;
    Acute infectious diseases of the lower respiratory tract (bronchitis, pneumonia);
    Infections of ENT organs (acute otitis media, sinusitis, tonsillitis);
    Sepsis;
    Diseases of the skin and soft tissues (secondary infected dermatosis, impetigo, erysipelas);
    Prevention of endocarditis and surgical infection.

Contraindications

Contraindications to the use of Amosin are:
    Liver failure;
    Bronchial asthma and pollinosis;
    Allergic diathesis;
    Lymphocytic leukemia;
    Infectious mononucleosis;
    Diseases of the gastrointestinal tract;
    Hypersensitivity to amoxicillin and other penicillins, as well as carbapenems and cephalosporins;
    Breastfeeding period;
    Children's age up to 3 years (for the dosage form in the form of capsules and tablets).
With caution Amosin prescribed to pregnant women and patients with renal insufficiency and bleeding in history.

Use during pregnancy and lactation

Use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother outweighs the potential risk to the fetus.
Use during lactation is contraindicated. If necessary, use during lactation should stop breastfeeding.

Instructions for use Amosin

The instructions for use indicate that Amosin is taken orally, before or after meals. Dosing regimen set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, the patient's age.
    Adults and children over 10 years old (with a body weight of> 40 kg) are prescribed 500 mg 3 times / day, and in severe cases, 0.75-1 g 3 times / day.
    Children from 5 to 10 years old are prescribed 250 mg 3 times / day, from 2 to 5 years old - 125 mg 3 times / day, and up to 2 years old - 20 mg / kg / day in 3 doses. The course of treatment is 5-12 days.
    Children under the age of 5 years, the drug is prescribed in the form of a suspension.
For the treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; When treating women, it is recommended to re-take the indicated dose
For acute infectious diseases of the gastrointestinal tract (paratyphoid fever, typhoid fever) and biliary tract, for gynecological infectious diseases, adults are prescribed 1.5–2 g 3 times / day or 1–1.5 g 4 times / day.
When leptospirosis, adults are prescribed 500-750 mg 4 times / day for 6-12 days.
When adults are under salmonellosis, 1.5–2 g 3 times / day for 2–4 weeks.
For the prevention of endocarditis with small surgical interventions, adults are prescribed at a dose of 3-4 g for 1 hour before the procedure. If necessary, appoint a repeated dose after 8-9 hours. In children, reduce the dose by half.
In patients with impaired renal function (CK from 15 to 40 ml / min), the interval between doses increases to 12 hours, in the terminal stage of chronic renal failure (CC <10 ml / min) the dose of Amosin should be reduced by 15-50% or the interval should be increased between doses up to 24 hours, with anuria - the maximum dose is 2 g / day.

Powder for suspension oral Amosin

The drug is intended for the preparation of suspensions taken orally. The finished suspension is taken before or after a meal.
To prepare the suspension from the powder, packaged in disposable bags, pour cooled boiled water into a cup, pour the contents of the bag and stir until an equilibrium suspension is obtained. The amount of water is measured, depending on the dose of amoxicillin in the package (to obtain a suspension containing 250 mg of amoxicillin in 5 ml of suspension). At a dose of amoxicillin in a 125 mg sachet take 2.5 ml of drinking water, at a dose of 250 mg - 5 ml of drinking water, at a dose of 500 mg - 10 ml of drinking water. The drug should be taken immediately after preparation of the suspension. Cup after taking the drug should be washed in running water and dry.
To prepare the suspension from the powder, packaged in jars or vials, measure 62 ml of cooled boiled water and add it in portions to the bottle or jar. While adding water, shake the jar or vial to form an equilibrium suspension. The finished suspension contains 50 mg of amoxicillin in 1 ml. Shake the vial before each use. Dosing of the suspension is carried out using a measuring spoon, included in the kit.
The duration of use and dosage of the drug Amosin determined by the doctor.
    Adults and children weighing more than 40 kg (over 10 years old) are usually prescribed 500 mg of amoxicillin three times a day. In severe disease, the dose is increased to 750-1000 mg of amoxicillin three times a day.
    Children aged 5 to 10 years, as a rule, appoint 250 mg of amoxicillin three times a day.
    Children aged 2 to 5 years, as a rule, are prescribed 125 mg of amoxicillin three times a day.
    Children under 2 years old usually take 20 mg of amoxicillin per kg of body weight three times a day.
    The average duration of therapy is from 5 to 12 days (as a rule, the drug is continued for 2-3 days after the disappearance of the clinical manifestations of the disease).
Specific regimens of drug therapy Amosin:
In the acute form of uncomplicated gonorrhea, adults are usually prescribed a single dose of 3000 mg of amoxicillin. Women may be prescribed to re-take the recommended dose of amoxicillin.
    In acute infectious diseases of the biliary tract and the gastrointestinal tract, as well as gynecological diseases, adults are usually prescribed amoxicillin 1500-2000 mg three times a day or amoxicillin 1000-1500 mg four times a day.
    When adults have leptospirosis, they usually take 500-750 mg of amoxicillin four times a day. The duration of the drug Amosin is from 6 to 12 days.
    When salmonellosis adults, as a rule, appoint 1500-2000 mg of amoxicillin three times a day. The duration of the drug Amosin is 2-4 weeks.
    For the prevention of endocarditis during minor surgical operations, adults are usually prescribed 3000–4000 mg of amoxicillin 60 minutes before the start of surgery. At high risk of endocarditis, repeat amoxicillin 8–9 hours after the first dose. Children are advised to reduce prophylactic doses of amoxicillin by half.
In case of kidney dysfunction and creatinine clearance from 15 to 40 ml / min, it is recommended to increase the interval between doses of amoxicillin to 12 hours (with a single dose of Amosin do not change).
In case of impaired renal function and creatinine clearance less than 10 ml / min, the dose of amoxicillin should be reduced by 15-50%.
The maximum recommended daily dose for anuria is 2000 mg of amoxicillin.
With prolonged use of amoxicillin, it is recommended to monitor the function of the hematopoietic system, liver and kidneys.

Side effects

According to the instructions to Amosin, taking the drug can cause the following undesirable effects:
    On the part of the urinary system - interstitial nephritis;
    From the central and peripheral nervous system - anxiety, agitation, ataxia, insomnia, behavior change, confusion, peripheral neuropathy, convulsive reactions, dizziness, headache;
    On the part of the digestive system - change in taste, nausea, vomiting, dysbiosis, diarrhea, glossitis, stomatitis, abnormal liver function, pseudomembranous enterocolitis;
    Allergic reactions - skin hyperemia, urticaria, erythema, rhinitis, angioedema, conjunctivitis, joint pain, fever, exfoliative dermatitis, eosinophilia, Stevens-Johnson syndrome, exudative erythema multiforme, heart shape, skin type, heart rate, heart rate, heart rate, heart rate, heart failure rate, heart rate, skin cramps, exfoliative dermatitis, eosinophilia, Stevens-Johnson syndrome
    From the side of the hematopoietic system - neutropenia, leukopenia, anemia, thrombocytopenic purpura.
In addition, the use of Amosin can cause tachycardia, superinfection, shortness of breath and vaginal candidiasis.

Overdose

It is necessary to properly understand from what Amosin helps, and in what cases it causes harm. Of course, drug overdose is unpleasant and dangerous to health. In the case of taking higher doses of the drug, patients may develop vomiting, nausea, diarrhea, pain in the epigastric region, possibly a violation of water and electrolyte balance.
In case of an overdose, the patient should wash the stomach and prescribe enterosorbent drugs. If overdose symptoms develop, symptomatic therapy should be prescribed. It is also advisable to assign saline laxatives, as well as carrying out procedures that support water and electrolyte balance.

special instructions

When using Amosin, it is necessary to monitor the state of the function of the kidneys, liver and blood-forming organs.
    During drug treatment, the development of superinfection is possible, which requires a change in antibacterial therapy.
    Patients with bacteremia may have a Jarish-Herxheimer reaction (bacteriolysis reaction), manifested by fever, chills, nausea, headache, tachycardia, a decrease in blood pressure and aggravation of symptoms of the underlying disease.
    In case of hypersensitivity to penicillins, the use of Amosin can cause allergic cross-reactions with cephalosporin antibiotics.
    With the simultaneous use of amoxicillin and oral contraceptives containing estrogen, it is recommended to use additional methods of protection against unwanted pregnancy.
    If mild diarrhea has occurred during the treatment with Amosin, the administration of drugs that reduce intestinal motility should be avoided. To do this, you can use attapulgite-or koalin-containing antidiarrheals. Severe diarrhea requires differential diagnosis and appropriate treatment.

Drug interactions

    Drugs that block tubular secretion, cause an increase in the concentration of amoxicillin, while the use of methotrexate increases the toxicity of the latter.
    With simultaneous use of amoxicillin with glucosamines, aminoglycosides, laxatives and antacids, slow absorption is noted, and when taken along with ascorbic acid, metabolism increases.
    When used concurrently with metronidazole, nausea, vomiting, diarrhea, and epigastric pain often develop.
    In a complex with clavulanic acid, the development of cholestatic jaundice, hepatitis, and multiforme erythema is possible.
    Interaction with Probenecid increases the serum concentration of the antibiotic and reduces its excretion from the body. Amosin, like other antibacterial drugs, reduces the effectiveness of oral contraceptives.
    Amosin synergists are cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine, sulfonamides, macrolides, tetracyclines and lincosamides are antagonists.
It is strictly contraindicated for simultaneous use with disulfiram. Special care should be taken when using amoxicillin and anticoagulants at the same time (this may cause prolongation of prothrombin time.

Reviews

If you have not yet decided whether to buy this drug, reviews about Amosin will help you evaluate it and make a decision.
Testimonials are mostly positive, many people write that for a fairly reasonable price, this drug has a fast action - in the shortest possible time it is able to remove the corresponding symptoms and speed up the process of treating an illness. An important fact is also the fact that in the course of treatment patients do not have any unpleasant sensations.
Irina
Amosin helps me a lot if I start drinking it right away at the first symptoms of inflammation - I have chronic bronchitis on the left and chronic bronchiectasis on the right. Coming from work, sometimes I feel an actively growing malaise and temperature, I drink the first double dose. A lot of liquid - preferably herbal teas. There was an interaction with alcohol - normal. But when a cold is running, this antibiotic is weak. “Junk” stomach with pancreas, but when you receive a large amount of fluid with the drug do not feel the complications.

Storage conditions

Keep out of reach of children, dry, dark place. Powder for the preparation of suspensions should be stored at a temperature not higher than 25 ° C.
The shelf life of the drug is 2 years.

Terms of sell

You don't need a prescription to buy Amosin.