Fexadin tabs 180mg #10

Instruction for Fexadin

Reed more and buy Fexadin here

Forms of release and composition

Tablets Fexadin film-coated 120, 180 mg (blisters).
Active ingredient - feksofenadin 120/180 mg.
Excipients: croscarmellose sodium, microcrystalline cellulose, corn starch, silicon dioxide, povidone, magnesium stearate, opadry pink.

Pharmacological group

H1-histamine receptor antagonist.

pharmachologic effect

    antihistamine;
    H1-histamine blocking.

Fexadin, indications for use

Seasonal allergic rhinitis (120 mg tablet), chronic idiopathic urticaria (180 mg tablet).

Dosage and administration

    seasonal allergic rhinitis: sneezing, itching, rhinitis, redness of the mucous membrane of the eyes and other symptoms of hay fever - table. 120 mg each;
    chronic idiopathic urticaria: redness, pruritus and other symptoms of urticaria - Table. 180 mg.

Pharmacokinetics

Fexofenadine hydrochloride after oral administration is rapidly absorbed from the gastrointestinal tract, Tmax - 1-3 hours. The average Cmax after taking a dose of 120 mg is 289 ng / ml, and after taking a dose of 180 mg - approximately 494 ng / ml. Plasma protein binding is 60-70% (mainly with albumin and alpha1-glycoprotein). Does not penetrate the BBB. Fexofenadine is subjected to partial (5% of the dose) metabolism.
Two-phase removal. T1 / 2 after repeated administration - 11-15 hours. In patients with moderate (Cl creatinine 41-80 ml / min) and severe (11-40 ml / min) renal failure, T1 / 2 increases by 59 and 72%, respectively; in patients on hemodialysis, T1 / 2 is increased by 31%. The pharmacokinetics with single and repeated use of fexofenadine (up to 120 mg twice a day) is linear.
Excreted mainly (80%) with bile, up to 10% of the accepted dose is excreted unchanged in the urine.

Pharmacodynamics

Fexofenadine hydrochloride is a blocker of H1-histamine receptors, almost devoid of sedative action. Fexofenadine is a pharmacologically active metabolite of terfenadine.
The antihistamine effect of the drug manifests itself after 1 h after administration, reaches a maximum after 6 h and lasts for 24 h. After 28 days of admission, the development of tolerance is not observed. With oral doses of 10 to 130 mg, there is a linear dose-response relationship. For a 24-hour drug efficacy (for allergic rhinitis), a dose of 120 mg is sufficient. At a dose of up to 240 mg, the drug does not cause changes in the QT interval.

Contraindications

Hypersensitivity.

Pregnancy and lactation

Perhaps if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Side effects of Fexadin

Headache, fatigue, drowsiness, dry mouth, nasal cavity and / or larynx; nausea, dyspepsia, tachycardia. In some patients may cause increased irritability, sleep disturbance. Very rarely - a violation of taste, anaphylactic reaction, chest pain, photosensitivity.

special instructions

In older patients or patients with hepatic insufficiency, fexofenadine should be used with caution due to the lack of data. It is recommended that the time between taking fexofenadine hydrochloride and antacids containing aluminum or magnesium hydroxide is 2 hours.
Influence on the ability to drive a car and perform work that requires attention When taking the drug Fexadin, it is possible to perform work that requires a high concentration of attention and quickness of psychomotor reactions (except for people who have a non-standard reaction to drugs). Thus, before proceeding to the implementation of these works (driving vehicles, driving mechanisms), you must first check the individual response to the drug.

Interaction

    Co-administration of the drug Fexadin with ketoconazole or erythromycin is accompanied by an increase in the concentration of fexofenadine by 2-3 times. This effect is due to increased absorption in the digestive tract, reduced bile excretion, or a significant decrease in gastrointestinal secretion.
    Antacids containing Al3 + or Mg2 + in the composition reduce the bioavailability of fexofenadine. The recommended time interval between doses is at least two hours.
    No clinically significant interaction of fexofenadine with omeprazole was registered.
    Fexadin does not interact with drugs whose metabolism occurs in the liver system.

Overdose

    dizziness,
    drowsiness
    dry mouth.
Treatment: in case of overdose, it is recommended to take standard measures to remove unabsorbed drug from the gastrointestinal tract; conducting symptomatic and supportive therapy. Hemodialysis is ineffective.

Storage conditions

In the dark place at a temperature of no higher than 20 ° C.
Shelf life - 2 years.

Reviews Fexadin

    Opinion pharmacist. Allergy pills Fexadin is a good drug in itself, asked friends of people who suffer from allergies - they all take it without problems for years. Therefore, I recommend Fexadin tablets, but it is necessary to read the abstract, all of a sudden something of the composition does not suit you.
Helena
    I started Polinoz every spring. And such that I even took time off at work and left for this not the most convenient time where it was still cool! No long-term blockade preparations for allergens, that is, no pollen was set. I came out on this tool by chance and suddenly I felt a very strong effect on me! For the first time survived flowering without itching, stuffy nose and cramping in the throat. Very light - no drowsiness.
Kseniya
    I chose this particular dosage because I always want to sleep from more. I have seasonal rhinitis, and simply allergy with a runny nose and sneezing and only in August, so I stock up with Fexadin in advance!
Irina
    It helps me to remove symptoms by about 50%. In general, I think it is individual. Now I went to read how they are recommended to take it - before, during or after meals. Do not write.
Andrew
    Fexadin is another drug prescribed by an allergist. To all the previous ones, I somehow get used to getting used to, not enough for the whole season. So I experienced the past summer on only Fexadin! One pill is enough for a day so that the nose does not leak, the eyes are not irritated, they do not choke in the throat. The price of tablets is high, but at least justified.

Terms of sell

You don't need a prescription to buy Fexadin.