Clarisens syrup 5mg/5ml 100ml

Clarisens user manual

To buy Clarisens syrup just add it to your shopping cart

pharmachologic effect

Antiallergic drug. Loratadin belongs to the group of competitive histamine antagonists, selectively blocks peripheral histamine H1 receptors. Loratadin affects the histamine-dependent stage of allergic reactions, as well as reduces the migration of eosinophils, limits the release of inflammatory mediators at the cellular stage of allergic reactions. Prevents the development and facilitates the course of allergic reactions, has anti-exudative and antipruritic action, practically does not have anticholinergic and antiserotonin action.
Does not penetrate the BBB, does not affect the central nervous system, does not cause addiction.
Antiallergic effect develops after 30 minutes and lasts 24 hours.

Pharmacokinetics

Suction

Quickly and completely absorbed from the digestive tract. The time to reach Cmax is 1.3-2.5 hours. Eating slows down the time to reach Cmax by 1 hour.

Distribution

Plasma protein binding - 97%. Css loratadine and its metabolite is achieved on the 5th day of administration. Does not penetrate the BBB.

Metabolism

Metabolized in the liver to form the active metabolite of descarboethoxyloratadine with the participation of CYP3A4 enzymes and, to a lesser extent, CYP2D6.

Removal

T1 / 2 loratadine - 3-20 hours (average 8.4 hours), active metabolite - 8.8-92 (average 28 hours).
Excreted in urine and bile.

Pharmacokinetics in special clinical situations

Cmax increases in elderly patients by 50%, T1 / 2 loratadine is 6.7-37 h (average 18.2 h), the active metabolite - 11-38 (average 17.5 h).
With alcoholic liver damage, Cmax and T1 / 2 increase in accordance with an increase in the severity of the disease.
In patients with chronic renal failure and during hemodialysis, the pharmacokinetics are virtually unchanged.

Dosage of the drug Clarisens

Adults and children over 12 years old are prescribed 10 mg each (1 tab. Or 10 ml of syrup) 1 time / day.
Children aged 2 to 12 years with a body weight of less than 30 kg - 5 mg (1/2 tab. Or 5 ml) 1 time / day, with a body weight of more than 30 kg - 10 mg (1 tab. Or 10 ml syrup) 1 time / day.
Clarisens is taken orally, regardless of the meal, with a small amount of water.

Drug interactions

Ethanol reduces the effectiveness of loratadine.
Erythromycin, cimetidine, ketoconazole increase the concentration of loratadine in the blood plasma, without causing clinical manifestations and without affecting the ECG.
Inductors of microsomal oxidation (phenytoin, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of loratadine.

The use of clarisens during pregnancy

The drug is contraindicated during pregnancy and during breastfeeding.

Use in childhood

Children aged 2 to 12 years with a body weight of less than 30 kg - 5 mg (1/2 tab. Or 5 ml) 1 time / day, with a body weight of more than 30 kg - 10 mg (1 tab. Or 10 ml syrup) 1 time / day.

Clarisens - side effects

The adverse effects listed below were observed with a frequency of ≥2% and approximately the same frequency as when taking placebo.
From the side of the central nervous system: in adults - headache, fatigue, drowsiness; in children - headache, nervousness, sedative effect.
On the part of the digestive system: in adults - dry mouth, nausea, gastritis, abnormal liver function.
Since the cardiovascular system: in adults - palpitations, tachycardia.
Allergic reactions: in adults - a rash, anaphylaxis.
Other: alopecia (in adults).

Terms of storage of the drug Clarisens

The drug should be stored in a dry, dark place, out of reach of children at a temperature of 25 ° C. Shelf life - 2 years.

Indications for use Clarisens

- seasonal and perennial allergic rhinitis and conjunctivitis;
- Quincke swelling;
- urticaria (including chronic idiopathic);
- allergic reactions to insect bites;
- pruritic allergic dermatosis (including chronic eczema, contact dermatitis).

Special instructions when taking clarisens

When liver failure drug prescribed every other day.
Influence on ability to drive motor transport and control mechanisms
During the period of treatment, one should refrain from engaging in potentially hazardous activities that require increased concentration of attention and quickness of psychomotor reactions.

Terms of sell

You can buy Clarisens without a prescription.