9 Months Folic acid 0.4mg #90

9 Months Folic acid user manual

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Composition

Tablets, film coated 1 tab.
active substance:
folic acid 400 mcg
excipients: lactose monohydrate (tablettose 80); colloidal silicon dioxide; Copovidone (Kollidon VA-64); magnesium stearate
film cover: Opadry II (series 85) (polyvinyl alcohol, macrogol, talc, titanium dioxide E171, iron oxide yellow E172, aluminum varnish based on quinoline yellow E104

Description of the dosage form

Tablets: biconvex, round-shaped, film-coated yellow.
On a break: light yellow color with splashes.

pharmachologic effect

Pharmacological action - compensating for folic acid deficiency.

Pharmacodynamics

Vitamin B (vitamin B, vitamin B9), can be synthesized by intestinal microflora. In the body, folic acid is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. Necessary for the normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis, participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine.

Pharmacokinetics

Folic acid is well and completely absorbed in the digestive tract, mainly in the upper parts of the duodenum. Almost completely bound to plasma proteins. It is activated in the liver under the influence of the enzyme dihydrofolate reductase, turning into tetrahydrofolic acid. Tmax - 30–60 min. Gets through the blood-brain and placental barriers into breast milk.
Excreted by the kidneys mainly in the form of metabolites; if the accepted dose significantly exceeds the daily need for folic acid, it is displayed in unchanged form.
Excreted through hemodialysis.

Indications drug 9 months Folic acid

folic acid deficiency;
prevention of the development of neural tube defects in the fetus in the first trimester of pregnancy.

Contraindications

hypersensitivity to 9 Months Folic acid;
pernicious anemia;
malignant neoplasms;
cobalamin deficiency;
childhood.

Use during pregnancy and lactation

Folic acid is necessary during the period of preparation for pregnancy (1-3 months before the planned pregnancy) and in the first few weeks after conception (I term).

Side effects of 9 Months Folic acid

Allergic reactions: skin rash, itching, bronchospasm, erythema, hyperthermia.
On the part of the digestive tract: nausea, bloating, bitterness in the mouth, anorexia.
With prolonged use may develop hypovitaminosis B12.

Interaction

Reduces the effect of phenytoin (requires an increase in its dose).
Analgesics (long-term therapy), anticonvulsant drugs (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.
Antacids, colestyramine, sulfonamines (including sulfasalazine) reduce the absorption of folic acid.
Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead of it, folinate should be prescribed to patients using these drugs).
With simultaneous use of chloramphenicol, neomycin, polymyxin, tetracycline absorption of folic acid is reduced.

Dosage and administration

Inside, after eating.
With a folic acid deficiency of 400 μg (1 tab.) Per day.
For the prevention of the development of neural tube defects in the fetus in the first trimester of pregnancy - 400–800 mcg (1-2 tablets).

Overdose

It may occur with long-term use (more than 1-2 months) of folic acid in doses of more than 1000 mg per day and as a result of joint use with vitamin-mineral complexes.

special instructions

For the prevention of hypovitaminosis, most preferably a balanced diet. Foods rich in folic acid - green vegetables (lettuce, spinach, tomatoes, carrots), fresh liver, legumes, beets, eggs, cheese, nuts, cereals.
Folic acid is not used for the treatment of B12-deficient (pernicious), normocytic and aplastic anemia, as well as refractory anemia to therapy. When pernicious (B12-deficient) anemia, folic acid, improving hematological parameters, masks neurological complications. While pernicious anemia cannot be ruled out, the administration of folic acid in doses exceeding 100 µg / day is not recommended (except for pregnancy and lactation).
It should be borne in mind that patients on hemodialysis need increased amounts of folic acid.
During treatment, antacids should be applied 2 hours after taking folic acid, Kolestiramine - 4-6 hours before or 1 hour after taking folic acid. It should be borne in mind that antibiotics may distort (to give obviously underestimated indicators) the results of microbiological evaluation of plasma and erythrocyte folate concentrations. With the use of large doses of folic acid, as well as therapy for a long period, a decrease in the concentration of vitamin B12 is possible.

Release form

Tablets, film coated, 400 mkg. In the packages of blister strip made of PVC film and aluminum printed lacquer foil, 10 pieces each. In a pack of cardboard 3, 6 or 9 packs.

Storage conditions of the drug for 9 months Folic acid

In the dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
Shelf life - 3 years.

Terms of sell

You don't need a prescription to buy 9 Months Folic acid.