Detralex suspension 1000mg/10ml 10ml #30

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Detralex suspension instruction for use

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Release form, composition

Oral suspension is homogeneous, light yellow in color, with a characteristic odor.
1 sachet (10 ml)
purified micronized flavonoid fraction of 1000 mg,
including Diosmin 900 mg (90%)
flavonoids in terms of hesperidin 100 mg (10%)
citric acid - 12.5 mg, orange flavor - 15 mg, maltitol - 1800 mg, sodium benzoate - 15 mg, xanthan gum - 50 mg, purified water q.s. - up to 10 ml.
10 ml - multi-layer sachets (15) - cardboard packs.
10 ml - multi-layer sachets (30) - cardboard packs.

pharmachologic effect

Detralex suspension has venotonic and angioprotective properties. The drug reduces the tensile properties of the veins and venous congestion, reduces capillary permeability and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug in relation to venous hemodynamic parameters.
The statistically significant dose-dependent effect of suspension Detralex was demonstrated for the following venous plethysmographic parameters: venous capacity, venous distensibility, venous emptying time. The optimal dose-effect ratio is observed when taking 1000 mg / day.
Detralex suspension increases venous tone: using venous occlusive plethysmography, a decrease in venous emptying time has been shown. In patients with signs of a pronounced microcirculation disorder after treatment with suspension Detralex, there is a (statistically significant, compared to placebo) increase in capillary resistance assessed by angiostereometry.
The therapeutic efficacy of suspension Detralex has been proven in the treatment of chronic venous diseases of the lower limbs, as well as in the treatment of hemorrhoids.
Detralex suspension reduces the undesirable side effects of invasive treatments for chronic vein diseases (reduces the incidence of undesirable side effects in the surgical and endovascular treatment of varicose veins: significantly reduces the intensity of postoperative pain, swelling and severity of hemorrhages after endovascular and surgical treatment).

Pharmacokinetics

The main excretion of the drug occurs with feces. With urine, on average, about 14% of the accepted amount of the drug. T1 / 2 is 11 hours.
The drug is subjected to active metabolism, as evidenced by the presence of phenolic acids in the urine.


Dosage and administration

The drug is taken orally.
The recommended dose for venous lymphatic insufficiency is 1000 mg (content of 1 sachet) per day, preferably in the morning, during the meal.
The duration of treatment can be several months (up to 12 months). In the case of recurrence of symptoms, according to the recommendation of a doctor, the treatment can be repeated.
The recommended dose for acute hemorrhoids is 3000 mg / day (1000 mg each (contents of 1 sachet) in the morning, afternoon and evening) for 4 days, then 2000 mg / day (1000 mg each (contents of 1 sachet) in the morning and evening) over the next 3 days.
The recommended dose for chronic hemorrhoids is 1000 mg (contents of 1 sachet) / day at any convenient time of the day with meals.

Overdose

Cases of overdose are not described.
In case of overdose, the patient should immediately seek medical attention.

Interaction with other drugs

Drug interaction of suspension Detralex was not observed.
The patient should inform the attending physician about all medications taken.

During pregnancy and breastfeeding

Pregnancy

In experimental animal studies, no teratogenic effects were identified.
To date, there have been no reports of adverse effects in the use of the drug in pregnant women.

Breastfeeding period

Due to the lack of data on the elimination of the drug in breast milk, breastfeeding women are not recommended to take the drug.

Reproductive Impact

Reproductive toxicity studies showed no effect on reproductive function in rats of both sexes.

Side effects

The side effects of Detralex suspension observed during clinical trials were mild. Disturbances from a gastrointestinal tract (diarrhea, dyspepsia, nausea, vomiting) were mainly noted.
While taking suspension Detralex, the following side effects were reported in the form of the following gradation: very often (> 1/10), often (> 1/100, <1/10), infrequently (> 1/1000, <1/100) , rarely (> 1/10 000, <1/1000), extremely rare (<1/10 000), unspecified frequency (frequency cannot be calculated from available data).
From the side of the central nervous system: rarely - dizziness, headache, general malaise.
On the part of the digestive tract: often - diarrhea, dyspepsia, nausea, vomiting; infrequently - colitis; unspecified frequency - abdominal pain.
For the skin: rarely - skin rash, pruritus, urticaria; unspecified frequency - isolated swelling of the face, lips, eyelids; in exceptional cases, angioedema.
The patient should inform the doctor about the appearance of any, incl. undesirable reactions and sensations not mentioned in the instructions, as well as changes in laboratory parameters during therapy.

Terms and conditions of storage

The drug should be stored out of reach of children at a temperature not exceeding 30 ° C. Shelf life - 3 years. Do not use after the expiration date printed on the package.


Indications

Detralex suspension is indicated for the treatment of symptoms of chronic venous disease (elimination and relief of symptoms).
Treatment of symptoms of venous lymphatic insufficiency:
- pain;
- convulsions of the lower extremities;
- feeling of heaviness and fullness in the legs;
- "tired" legs.
Therapy of manifestations of venous lymphatic insufficiency:
- swelling of the lower extremities;
- trophic changes in the skin and subcutaneous tissue;
- venous trophic ulcers.
Symptomatic therapy of acute and chronic hemorrhoids.

Contraindications

- hypersensitivity to the active substance or excipients that are part of the drug;
- fructose intolerance.
The use of the drug is not recommended for lactating women.

special instructions

Before starting the use of suspension Detralex, the patient is advised to consult a doctor.
In case of exacerbation of hemorrhoids, the prescription of the drug Detralex suspension does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the time specified in the section "Dosage regimen". In the event that the symptoms do not disappear after the recommended course of therapy, a proctologist should be examined, who will select further therapy.
In the presence of disorders of the venous circulation, the maximum effect of treatment is provided by a combination of therapy with a healthy (balanced) lifestyle; It is advisable to avoid long stay in the sun, long stay on the legs, and it is also recommended to reduce overweight. Hiking and, in some cases, wearing special stockings (compression knitwear) helps to improve blood circulation.
The patient should immediately consult a doctor if the condition worsens or there is no improvement in the treatment process.

Influence on ability to drive motor transport and control mechanisms

The drug does not affect the ability to drive and perform work that require high speed mental and physical reactions.

Terms of sell

You can buy Detralex suspension without a prescription.