Colchicum-Dispert tabs 0.5mg #20

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Instruction for Colchicum-Dispert

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Colchicum-Dispert is a drug that affects the metabolism of uric acid, an anti-gout agent.

Release form and composition

Dosage form - coated tablets: round, dark red, with a shiny surface (20 pcs. In a blister, 1 blister in a cardboard box; 25 pcs. In a blister, 2 blisters in a cardboard box).
Active ingredient: dry extract of autumn colchicum seeds, in 1 tablet - 15.6 mg, which corresponds to the content of the sum of alkaloids in terms of colchicine - 0.5 mg.
Additional components: corn starch, white wax, cochineal carmine A, palmitic / stearic acid, sucrose, sodium carmellose, light magnesium oxide, povidone K25, gum arabic, copovidone, magnesium stearate, carnauba wax, microcrystalline cellulose, titanium oxide, sodium macrogol 6000 sulfate, lactose monohydrate, talc, shellac, amaranth dye (E123).

Pharmacodynamics

Colchicine - the active component of Colchicum-Dispert - has an anti-gout effect due to inhibition of the phagocytosis of microcrystals of uric acid salts and a decrease in the migration of leukocytes to the inflammation focus. It is also characterized by antimitotic action. The drug completely or partially inhibits cell division in the metaphase and anaphase stages, prevents neutrophil degranulation and prevents the development of amyloidosis by suppressing the formation of amyloid fibrils.
Colchicine is highly effective in relieving attacks of acute gout. In the first 12 hours after the start of taking the drug, the condition improves significantly in more than 75% of patients. In 80% of patients, side reactions from the gastrointestinal tract may occur before or simultaneously with clinical improvement.
Taking Colchicum-Dispert every day in a daily dose of 1-2 mg reduces the risk of recurrent acute attacks in 3/4 of patients suffering from gout. The drug is a means of preventing acute attacks in patients with familial Mediterranean fever (by reducing the activity of dopamine beta-hydroxylase). Treatment with Colchicum-Dispert increases life expectancy in patients with primary AL-amyloidosis and has a positive effect on the condition of the skin (softens and reduces dryness) in systemic scleroderma.

Pharmacokinetics

Colchicine is intensively and rapidly absorbed from the gastrointestinal tract. Its maximum plasma level averages 4.2 ng / ml and is reached approximately 70 minutes after taking a dose of 1 mg. The half-life is 9.3 hours. Colchicine has a high volume of distribution (473 liters) and rapidly penetrates into tissues. High concentrations of this substance are determined in the gastrointestinal tract, liver, spleen, kidneys and leukocytes. Colchicine is involved in metabolic processes in the liver and is excreted mainly in the bile.
Enterohepatic circulation is recorded 4–6 hours after colchicine enters the body. Most of the dose received is excreted through the intestines and about 23% through the kidneys.

Indications for use

    Acute gout attacks;
    Familial Mediterranean fever (periodic illness).

Contraindications

Absolute:
    Pronounced suppression of bone marrow hematopoiesis;
    Hepatic or renal impairment;
    Pregnancy and lactation;
    Hypersensitivity to the drug.
Relative:
    Severe dysfunction of the cardiovascular system;
    Severe dysfunction of the gastrointestinal tract;
    Cachexia;
    Elderly age.


Instructions for use Colchicum-Dispert: method and dosage

The tablets should be taken orally: swallow them whole and drink them with a sufficient amount of liquid.
To relieve an acute attack of gout, you first need to take 2 tablets at once, then 1-3 tablets every 1-2 hours until the pain syndrome subsides. The total daily dose should not exceed 8 mg (16 tablets). In case of a new attack of gout, it is possible to carry out repeated treatment according to the described scheme, but not earlier than 3 days later.
For the prevention of acute attacks of gout, the drug is prescribed 1-3 tablets daily or every other day for the first few months (usually 3) of treatment with uricosuric drugs.

Side effects

Possible: stomach pain, nausea, vomiting, diarrhea, in rare cases - leukopenia.
With prolonged use of the drug in some cases, myopathy and neuropathy occur, even less often - hypoplastic anemia, agranulocytosis, alopecia.

Overdose

Symptoms of acute drug intoxication were observed in adults after taking a dose of about 20 mg and in children after taking a dose of 5 mg.
Chronic intoxication is observed in patients suffering from gout after taking Colchicum-Dispert in a total dose of 10 mg or higher for several days.
Since colchicine is characterized by antimitotic activity, organs in which an increased proliferation rate is observed are most often affected.
Approximately 2-6 hours after taking the drug in doses exceeding the therapeutic one, patients develop thirst, difficulty swallowing, a sore throat and a burning sensation in the throat and mouth, nausea, vomiting and urge to it, and after a short period of time - colic , tenesmus, urge to urinate and defecate (usually in emaciated patients).
Hemorrhagic and / or muco-watery diarrhea can lead to loss of fluid and electrolytes, which leads to the development of metabolic acidosis, hyponatremia and hypokalemia. Often, patients complain at the same time of pain and a feeling of tightness in the region of the heart. In the future, they have dyspnea, a decrease in body temperature, pallor and cyanosis of the skin. The development of tachycardia and arterial hypotension, ending in collapse, is not excluded.
Neurological disorders are expressed in the form of seizures, weakening sensitivity and signs of paralysis. In the first 3 days, a lethal outcome is possible due to paralysis of the respiratory center and cardiovascular failure.
After 1-2 weeks after treatment, intoxication in patients may appear complete, sometimes prolonged alopecia. In some cases, dysfunctions of the liver, kidneys and lungs are noted. Occasionally, patients are struck by blindness.
In case of an overdose, only symptomatic treatment is possible, aimed at stabilizing the cardiovascular system. Plasma substitutes or isotonic sodium chloride solution with the addition of electrolytes (mainly potassium) and glucose are injected intravenously. Continuous ECG monitoring is recommended.
Digoxin is prescribed to normalize myocardial contractility. If necessary, antibiotic therapy is performed. If an increased pressure of cerebrospinal fluid is detected, the use of dexamethasone is recommended, and, if necessary, a lumbar puncture. For abdominal cramps, it is advisable to use papaverine, atropine or tanalbin. The prescription of opiates is prohibited. If necessary, artificial respiration or oxygen therapy sessions are performed.


Special instructions

During treatment, it is necessary to carry out clinical and hematological control.
With the development of pronounced side effects from the digestive system, the dose of the drug should be reduced or canceled altogether.
In the case of a decrease in the number of platelets below 100,000 / μl and leukocytes below 3000 / μl, the use of the drug is discontinued until the blood picture is normalized.
According to the instructions, Colchicum-Dispert does not adversely affect the speed of reactions and the patient's ability to concentrate.

Use in the elderly

The drug is prescribed with extreme caution to elderly patients.

Drug interactions

    Cyclosporine: the likelihood of developing myopathy increases, especially in patients with functional impairment of the kidneys;
    Cyanocobalamin: its absorption is impaired;
    Deprimating and sympathomimetic agents: their effect is enhanced;
    Non-steroidal anti-inflammatory drugs and other drugs that cause myelodepression: the risk of thrombocytopenia and leukopenia increases;
    Cytostatics and urine acidifying drugs: the anti-gout activity of colchicine decreases;
    Urine alkalizing agents: enhances the effect of colchicine.
If necessary, Colchicum-Dispert can be used simultaneously with allopurinol and uricosuric drugs.

Terms and conditions of storage

Store out of the reach of children and protected from light. Do not exceed a temperature of 25 ºС.
The shelf life is 5 years.

Reviews about Colchicum-Dispert

According to reviews, Colchicum-Dispert relieves gout attacks well and, with systematic treatment, eliminates purine metabolism disorders. The greatest effect can be achieved if the drug is used in the first hours after the onset of an attack.
The drug ensures the retrograde development of arthritis for several hours, but it must be taken every 2 hours until the pain practically disappears (no more than 16 tablets per day). However, patients say that due to the development of side effects - nausea, vomiting, diarrhea, hemorrhagic gastroenteritis - it is often not possible to increase the dose to the optimal one.
Since the drug is toxic, some experts practice the prescription of colchicine in small doses and non-steroidal anti-inflammatory drugs in combination. It should also be taken into account that the toxicity of drugs increases when they are taken by patients with kidney disease.

Terms of sell

You can buy Colchicum-Dispert without a prescription.