Clindacin B prolong cream 2% + 2% 20gr

Instruction for use Clindacin B

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Clindacin B is a local combination drug with antifungal and antibacterial action, used in gynecology.

Release form and composition

The dosage form of Clindacin B is a vaginal cream: from almost white with a grayish tinge to white, has a specific odor (6 or 20 g in aluminum tubes, in a cardboard box 1 tube complete with 1 or 3 applicators).
The composition of 100 mg of cream contains:
    active substances: butoconazole nitrate - 2 mg; clindamycin - 2 mg (clindamycin phosphate - 2.376 mg);
    auxiliary components: isopropyl myristate - 8 mg; propylene glycol - 5 mg; cetostearyl alcohol (stearyl alcohol - 40%; cetyl alcohol - 60%) - 6 mg; macrogol cetostearate - 2 mg; sodium hydroxide - 0.26 mg; hydroxypropyl dichloromethane phosphate - 8 mg; preservative Euxyl PE 9010 (ethylhexylglycerol - 10%; phenoxyethanol - 90%) - 0.5 mg (equivalent to phenoxyethanol - 0.45 mg); purified water - up to 100 mg.

Pharmacodynamics

Butoconazole is an imidazole derivative that has fungicidal activity against fungi of the genera Epidermophyton, Candida, Microsporum, Trichophyton and some gram-positive bacteria. The substance is most effective for candidiasis. Blocks the formation of ergosterol from lanosterol in the cell membrane, which increases membrane permeability and causes lysis of fungal cells.
Clindamycin is a bacteriostatic antibiotic from the lincosamide group. It binds to the 50S subunit of the ribosomal membrane and inhibits protein synthesis in the microbial cell. Possesses a wide spectrum of action. In relation to some gram-positive cocci, it can have a bactericidal effect. Active against Fusobacterium spp., Streptococcus spp. (excluding Enterococcus faecalis), Staphylococcus spp. (including Staphylococcus epidermidis, producing and non-producing penicillinase), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., anaerobic and microaerophilic gram-positive cocci (including Peptococcus Cloccus Cloccus spp. and Peptostreti. spp. and Peptostreptocides) (including Bacteroides fragilis and Prevotella melaninogenica), Propionibacterium spp., eubacterium spp. and Actinomyces israelii. Most strains of Clostridium perfringens are susceptible to clindamycin, but other Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its effects. In this regard, in infections associated with Clostridium spp., It is recommended to determine the antibiogram.
Due to the hydrophilic cream base, at a temperature of 35–40 ° C, the preparation acquires a gel-like consistency. Clindacin B does not melt when used intravaginally, and therefore the active ingredients remain on the vaginal mucosa for 1-3 days.
Cross-resistance exists between lincomycin and clindamycin.

Pharmacokinetics

Absorption with intravaginal administration: butoconazole - about 1.7% of the administered dose, clindamycin - 4%.
The maximum plasma concentration of butoconazole in the blood is 2-18.6 ng / ml (reached after 13 hours), clindamycin is 20 ng / ml.
Butoconazole undergoes intensive metabolism, partially excreted by the intestines and kidneys.

Indications for use

Clindacin B prolonged cream is prescribed for the treatment of bacterial, fungal and mixed vaginosis caused by microorganisms that are sensitive to the action of the drug.

Contraindications

Absolute:
    ulcerative colitis (including a burdened history);
    Crohn's disease;
    pseudomembranous colitis (including a burdened history);
    age under 18;
    individual intolerance to the components of the drug, including hypersensitivity to lincomycin, clindamycin or butoconazole.
Relative (diseases / conditions in the presence of which the appointment of Clindacin B requires caution):
    allergic diseases;
    combination therapy with muscle relaxants;
    pregnancy and breastfeeding period.

Instructions for the use of Clindacin B: method and dosage

Clindacin B prolonged cream is injected intravaginally using an applicator, preferably at bedtime. The applicator should be inserted horizontally as far as possible into the vagina without causing any discomfort. The applicator is considered completely full when its piston reaches the stop.
The recommended dose is 1 full applicator (5 g of cream). It is applied daily 1 time a day for a course of 3 days.

Side effects

Clindacin B prolonged is generally well tolerated.
Possible violations: cramps / pain in the lower abdomen, irritation at the injection site, burning, itching, swelling and soreness of the vaginal mucosa, allergic reactions.

Overdose

Overdose with intravaginal application of Clindacin B prolonged cream was not observed.

Special instructions

If, after completion of treatment, clinical signs of infection persist, a repeated microbiological examination is indicated in order to identify the pathogen and confirm the diagnosis.
If painful sensations or irritation of the vaginal mucosa appear, therapy is canceled.

Application during pregnancy and lactation

The possibility of using Clindacin B during pregnancy and breastfeeding is assessed by the doctor individually based on the benefit / risk ratio.

Childhood use

According to the instructions, Clindacin B is not prescribed to patients under 18.

Drug interactions

Simultaneous therapy with other drugs for intravaginal use is not recommended.
Clindacin B is incompatible with solutions containing a complex of B vitamins, ampicillin, aminoglycosides, magnesium sulfate and calcium gluconate.
There is an antagonistic interaction between erythromycin and clindamycin.

Terms and conditions of storage

Store in a place protected from light and moisture at a temperature of 15-25 ° C. Keep out of the reach of children.
Shelf life is 2 years.

Reviews of Clindacin B

According to reviews, Clindacin B is an effective drug, the effect of which is observed after the first use. The convenience of a short treatment course is noted. But it is necessary to take into account the likelihood of developing adverse reactions.

Terms of sell

You don't need a prescription to buy Clindacin B.