Lactinet tabs 75mcg #28


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Lactinet user manual

You can buy Lactinet here

Lactinet is a progestogen preparation for oral contraception.

Release form and composition

Dosage form of Lactinet - film-coated tablets: almost white or white, round biconvex shape, marked "D" on one side, "75" on the other (28 pieces in blisters, in a carton pack 1 or 3 blisters ).
The active substance is desogestrel, in 1 tablet - 0.075 mg.
Auxiliary components: colloidal silicon dioxide, D,L-α-tocopherol, stearic acid, potato starch, lactose monohydrate, povidone K30, magnesium stearate.
The composition of the film shell: Opadry II white (macrogol 3000, titanium dioxide (E171) CI 77891, polyvinyl alcohol, talc).


Lactinet is a monocomponent gestagen-containing oral contraceptive, including desogestrel, a progestogen, as an active substance, which can be taken by breastfeeding mothers, women if they have contraindications to estrogen, and also if they do not want to take contraceptives, which include estrogen.
Unlike other progestogen contraceptives, Lactinet only inhibits the process of ovulation. This fact is confirmed by the absence of an ovulatory follicle on ultrasound, the absence of an increase in the values ​​of luteotropic hormone and progesterone in the blood serum in the middle of the menstrual cycle.
Like other progestogens, desogestrel increases the viscosity of the cervical mucus, which prevents the advancement of spermatozoa.
The Pearl Index (an indicator that reflects the number of pregnancies among 100 women who used a contraceptive for 1 year) is 0.4. This number is comparable to that when using combined hormonal oral contraceptives.
Lactinet reduces the content of estradiol in the blood plasma to values ​​corresponding to the early follicular phase. The drug affects lipid and carbohydrate metabolism.


Desogestrel is rapidly absorbed after oral administration. The maximum concentration is reached after 1.8 hours. Its bioavailability is about 70%.
It is characterized by a high connection with plasma proteins - 95-99%, mainly with albumin, to a lesser extent - with SHBG (globulin that binds sex hormones). Steady-state plasma concentration is established 4–5 days after the start of Lactinet administration.
It is metabolized by hydroxylation and dehydrogenation to form the active metabolite of etonogestrel, which, in turn, is metabolized by the formation of sulfate and glucuronide conjugates.
Etonogestrel and its metabolites are excreted as conjugates and free steroids by the kidneys and through the intestines (in a ratio of 1.5:1).
The half-life of the drug averages 30 hours, both after a single dose and with multiple doses.
In breastfeeding women, etonogestrel passes into breast milk in a ratio of 0.37–0.55. Thus, a newborn who consumes approximately 150 mg/kg of milk per day can receive 0.01-0.05 mcg/kg of etonogestrel.

Indications for use

The use of Lactinet is indicated for women for oral contraception.


    Liver failure, including history;
    Severe abnormal liver function, including history (before recovery of liver function tests);
    Venous thromboembolism, including deep vein thrombosis of the lower extremities and pulmonary embolism (including those indicated in the anamnesis);
    Suspected or diagnosed malignant hormone-dependent neoplasms, including liver and breast cancer;
    Vaginal bleeding of unknown etiology;
    Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
    Prolonged immobilization caused by a serious illness or surgery;
    Confirmed pregnancy or suspicion of its presence;
    Hypersensitivity to the components of the drug.
According to the instructions, Lactinet should be administered with caution to patients with resistant arterial hypertension that develops against the background of the absence of the effect of antihypertensive therapy or the drug, systemic lupus erythematosus, chloasma (especially when indicating chloasma during pregnancy in history), porphyria, herpes (during pregnancy history), diabetes mellitus.

Instructions for use: method and dosage

Lactinet is taken orally, 1 tablet 1 time per day with a small amount of liquid.
Having determined the time of admission for herself, a woman must strictly adhere to it throughout the entire period of therapy, the interval between taking two tablets should not exceed 24 hours.
The use of Lactinet does not imply a break in the intake, the next day after the end of the tablets in the blister, it is necessary to take a tablet from a new blister.
If a woman did not use oral contraceptives in the previous menstrual cycle, you can start taking Lactinet on the first day of menstrual bleeding and then follow the direction indicated on the package. Additional contraceptive measures in this case are not required.
When you start taking the drug from 2 to 5 days of menstruation during the first 7 days of taking the tablets from the first blister, additional contraceptives should be used.
When switching from another oral combined contraceptive, the first Lactinet tablet must be taken the next day after the last tablet of the previous drug, without resorting to additional contraceptive measures.
When switching from a progestogenic contraceptive (mini-pill), you can start taking Lactinet on any day, with an injection - on the day of the expected next injection, with an implant - on the day of its removal. In any of these cases, it is necessary to use barrier contraceptives for the first 7 days.
When carrying out an abortion in the first trimester of pregnancy, it is recommended to start taking the pills directly on the day of the abortion without using additional methods of contraception.
Taking Lactinet during an abortion in the second trimester of pregnancy or after childbirth should be started after 21-28 days. In the case of a later start of therapy, it is necessary to use barrier contraceptives for the first 7 days. Moreover, women who had sexual intercourse (unprotected) during this period should exclude the presence of pregnancy or start taking the drug on the first day of the next menstrual bleeding (when the menstrual cycle resumes).
The effectiveness of the tablets is reduced if there is a break between taking two tablets for more than 36 hours.
If a woman forgot to take a pill at the set time and remembered about it within the next 12 hours, the effect of Lactinet does not decrease. The use of the following tablets should be continued as usual without additional contraceptives.
If the delay in admission exceeds 12 hours (more than 36 hours from the moment the last pill was taken), the contraceptive effect of Lactinet may decrease. Therefore, in the next 7 days of subsequent oral contraception, additional contraceptive methods must be used.
If the delay in taking the next pill by more than 12 hours occurred in the first week of taking the drug, and during this period the woman had unprotected sexual contact, then there is a high risk of pregnancy.
If after taking Lactinet during the first 3-4 hours the woman vomited, then the absorption process of the drug has not been completed. To maintain the achieved contraceptive effect, you must take the appropriate pill from the new package.
Menstrual irregularities can also occur with regular pill intake. If menstrual bleeding appears irregularly and very often, it is necessary to consider the use of another drug or methods of contraception. While maintaining menstrual disorders, the presence of an organic cause should be excluded.
The occurrence of amenorrhea during the period of use of the drug may be due to a violation of the regimen and the presence of pregnancy. When pregnancy is confirmed, you should immediately stop taking the pills.
Lactinet does not protect against infection with sexually transmitted diseases, including HIV infection (AIDS).

Side effects

The use of Lactinet can cause side effects:
    Often: menstrual irregularities, nausea, acne, mood changes, headache, decreased libido, weight gain, breast tenderness;
    Uncommon: dysmenorrhea, vomiting, alopecia, contact lens discomfort, fatigue, vaginitis, ovarian cysts;
    Rare: rash, skin redness, erythema nodosum, urticaria;
    Perhaps: the exact relationship with the drug has not been established - itching, cholestatic jaundice, chorea, cholelithiasis, herpes in pregnancy, deafness, otosclerosis, the appearance of hemolytic-uremic syndrome.
In the event of the appearance or aggravation of these undesirable reactions of the body to Lactinet, it is necessary to consult your doctor for advice.


In case of an overdose of Lactinet, spotting or bleeding from the vagina, nausea and vomiting may occur.
There is no specific antidote for desogestrel, treatment is symptomatic.

Special instructions

The use of Lactinet should be started on the recommendation of a doctor who, based on clinical indications and risk factors, should make a conclusion about the safety of hormonal contraception for a particular patient.
If side effects occur while taking pills or a risk factor, you should immediately consult a doctor for advice.
Regular medical supervision is required for women with diabetes during the first months of therapy.
Prevention of ectopic pregnancy with progestogen-containing contraceptives is less pronounced than with combined oral contraceptives.
The drug inhibits ovulation, however, the presence of an ectopic pregnancy with the appearance of abdominal pain or amenorrhea cannot be ruled out.
Lactinet helps to reduce the level of estradiol in the blood to the levels corresponding to the early follicular phase.
The use of the drug during breastfeeding is shown.
Against the background of taking pills, the development of chloasma is possible, more often in patients with a history of chloasma of pregnant women. Women prone to chloasma are advised to avoid direct sunlight and ultraviolet radiation while taking the drug.
Due to the content of lactose monohydrate in tablets, Lactinet should not be taken by women with such rare hereditary pathologies as lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Influence on the ability to drive vehicles and complex mechanisms

The use of the drug does not affect the ability to drive vehicles and mechanisms.

Use during pregnancy and lactation

Lactinet is contraindicated during pregnancy.
In preclinical studies, masculinization of the female fetus was observed due to the use of progestogen in high doses. In the course of epidemiological studies, there was no increased risk of developing a teratogenic effect and the formation of birth defects in children whose mothers took a contraceptive before pregnancy or unintentionally in early pregnancy.
Since Lactinet contains only progestogen, it does not affect the quantity and quality of mother's milk, however, a small amount of etonogestrel (the main metabolite of desogestrel) is excreted in breast milk. With a daily intake of 150 ml / kg of milk, a newborn receives 0.01-0.05 mcg / kg of the drug per day. During the 7-month follow-up of newborns whose mothers took progestogen, there were no increased risks in terms of growth, physical and psychomotor development. Nevertheless, it is recommended to carefully monitor the growth and development of infants if their mothers take Lactinet for contraception.

For impaired liver function

The appointment of Lactinet is contraindicated in patients with hepatic insufficiency, present or in history.
You should not take the drug if you currently have or have a history of severe liver disease until the indicators of liver function are normalized.

Drug interaction

With the simultaneous use of Lactinet with inducers of microsomal liver enzymes, such as phenytoin and other hydantoin derivatives, topiramate, rifabutin, primidone, barbiturates, griseofulvin, rifampicin, carbamazepine, oxcarbazepine, felbamate, the contraceptive effect of the drug decreases and the risk of breakthrough bleeding increases. If it is necessary to take these funds, you should temporarily additionally use barrier methods of contraception. Achieving the maximum induction of microsomal liver enzymes occurs no earlier than 2-3 weeks of therapy with the appropriate inducer and continues to persist no more than 4 weeks after discontinuation.
With other drugs, specialized studies on the interaction of desogestrel have not been conducted.
Ampicillin, tetracycline and other antibiotics reduce the effectiveness of oral contraceptives. Therefore, during the entire period of treatment with these drugs and 7 days after their withdrawal, a woman must additionally use barrier contraceptives.
In the case of simultaneous use of activated charcoal, additional contraception will be needed within 7 days after its cancellation.

Terms and conditions of storage

Store below 25°C. Keep away from children.
Shelf life - 3 years.


Doctors speak positively about Lactinet. They note that in the absence of contraindications and compliance with all recommendations, the drug is well tolerated even with prolonged use. An additional advantage is the possibility of taking Lactinet during lactation, as well as in the presence of contraindications to combined oral contraceptives.
Reviews about Lactinet from women who used it for contraception are mostly positive. The drug protects against unwanted pregnancy, is a low-dose hormonal agent, is taken once a day, does not cause a side effect in the form of weight gain, and is cheaper than analogues.
In separate negative reviews, women write about a change in the menstrual cycle (an increase in the duration and / or an increase in the intensity of menstruation), a decrease in libido, hair loss, and a rash on the face.

Terms of sell

You can buy Lactinet without a prescription from a doctor.