Analgin injections 50% 2ml #10

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User manual for Analgin injections

You can buy Analgin injections here

Composition

1 ml of the medicinal product contains: active ingredient - metamizole sodium - 500 mg; excipient - water for injection.

pharmachologic effect

The non-steroidal anti-inflammatory agent (NSAID), a pyrazolone derivative, is practically the same as other NSAIDs (non-selectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid). Interferes with carrying out of b-lev extra-and proprioreceptive impulses on beams of Gaulle and Burdakh, raises the threshold of excitability of the thalamic centers of pain sensitivity, increases heat transfer. A distinctive feature is the slight severity of the anti-inflammatory effect, causing a weak effect on water-salt metabolism (Na + retention and water) and the gastrointestinal mucosa (GIT). It has analgesic, antipyretic and some antispasmodic (in relation to the smooth muscles of the urinary and biliary tract) action.

Pharmacokinetics

After intramuscular administration, it is rapidly absorbed and enters the liver, where it undergoes hydrolysis to form the active metabolite 4-methylaminoantipyrine (4-MAA) and is demethylated to the second active metabolite, 4-aminoantipyrine (4-AA), and also biotransformed to inactive metabolites - 4- formylaminoantipirin (4-FAA) and 4-acetylaminoantipirin (4-AcAA). Unchanged analgin is detected in the blood in small quantities only after intravenous administration. In blood, reversibly binds to plasma proteins (4-MAA at 58%, 4-AA at 48%). The effective concentration of the amount of analgin metabolites is 10 μg / ml. The toxic effect is manifested when the concentration of metabolites in excess of 20 μg / ml. With repeated administration of Analgin injections, its pharmacokinetics do not change. Cumulation of the drug is not marked.
The total systemic clearance of the active metabolites 4-MAA and 4-AA is (182.9 ± 15.1) ml / min and (55.2 ± 6.4) ml / min, respectively. The period of their half-elimination (T½) is 2.5-3.0 h and 6-8 h, respectively. Excreted in the form of metabolites in the urine.
In patients with impaired liver and kidney function, while observing the recommended dosing regimen, no cumulation of the unchanged active substance is noted. Changes in pharmacokinetics in children aged 3 years, the elderly over the age of 70 years, as well as during pregnancy - not established.


Indications for use

Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies, etc., post-transfusion complications). Pain syndrome (mild to moderate): incl. neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, injuries, burns, decompression sickness, shingles, orchitis, sciatica, myositis, postoperative pain, headache, toothache, algomenorrhea, etc.

Contraindications for Analgin injections

Children in the first 3 months of life, weighing up to 5 kg, kidney disease (pyelonephritis, glomerulonephritis - including a history), hypersensitivity, hematopoietic suppression (agranulocytosis, cytostatic or infectious neutropenia), hepatic and / or renal failure, hereditary hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency, “aspirin” asthma, anemia, leukopenia, pregnancy (especially in the first trimester and in the last 6 weeks), the lactation period.

Carefully

Prolonged alcohol abuse. Intravenous administration to patients with systolic blood pressure below 100 mm Hg. or with instability of blood circulation (for example, against the background of myocardial infarction, multiple trauma, starting shock).

Dosage and administration

Intramuscularly or intravenously (especially with severe pain).
Adults - 250 - 500 mg 3 times a day. The maximum single dose - 1 g daily - 2 g.
Children are prescribed at the rate of 5-10 mg / kg 2-3 times a day. Children under 1 year of Analgin injections is administered only intramuscularly, the course of use - no more than 3 days.
Injectable solution Analgin for injection should have a body temperature.
Doses of more than 1 g should be administered intravenously.
It is necessary to have conditions for anti-shock therapy.
The most common cause of a sharp drop in blood pressure is an excessively high rate of injection, and therefore intravenous administration should be carried out slowly (at a rate of no more than 1 ml / min), while lying down, under the control of blood pressure, heart rate and breathing rate.

Side effect of Analgin injections

On the part of the urinary system: renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.
Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, an anemus, an anemus, an anemus, an anemus, an anemic syndrome, an epidermal necrolysis
From the side of blood-forming organs: agranulocytosis, leukopenia, thrombocytopenia.
Other: lowering blood pressure.
Local reactions: intramuscular administration may cause infiltrates at the injection site.

Overdose

Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, lowering blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or hepatic insufficiency, convulsions, respiratory paralysis, levitator musculoskeletal syndrome, acute renal and / or hepatic insufficiency, convulsions, respiratory paralysis.
Treatment: induction of vomiting, gastric lavage, saline laxatives, activated carbon; conducting forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous administration of diazepam and rapidly acting barbiturates.


Interaction with other drugs

Due to the high likelihood of developing pharmaceutical incompatibility, it should not be mixed with other drugs in the same syringe. Enhances the effects of ethanol; simultaneous use with chlorpromazine or other phenothiazine derivatives may lead to the development of severe hyperthermia. Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during treatment with analgin. With the simultaneous appointment of cyclosporine decreases the concentration of the latter in the blood. Analgin, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from the connection with the protein, increases their activity. Phenylbutazone, barbiturates, and other inducers of microsomal liver enzymes, while simultaneously prescribing, reduce the effectiveness of metamizol. Simultaneous administration with other non-narcotic analgesics, tricyclic antidepressants, hormonal contraceptives and allopurinol can lead to increased toxicity. Sedatives and anxiolytics (tranquilizers) increase the analgesic effect of analgin. Tiamazol and cytostatics increase the risk of leukopenia. The effect is enhanced by codeine, H2-histamine blockers and propranolol (slows down inactivation).

Precautionary measures

Pregnancy

Analgin injections use during pregnancy is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus. Analgin injections should be prescribed in the minimum effective dose. The use of dipyrone in the first trimester of pregnancy and in the last 6 weeks of pregnancy is not recommended.

Lactation period

Active metabolites injections analgin penetrate into breast milk. If necessary, the use of dipyrone in women during lactation should wean the child from the breast for the entire period of use of the drug.

Use in pediatrics

Analgin injections is not recommended for children in the first 3 months of life due to an increased risk of developing renal dysfunction.

Prolonged use of analgin injections (more than 7 days)

If necessary, regular use of dipyrone over 5 days should be monitored weekly picture of peripheral blood.

Acute abdominal pain

It is not recommended to use dipyrone for relief of acute abdominal pain before finding out its cause.

Use in persons with pathology of the cardiovascular system

Careful hemodynamic control is necessary, especially in patients with a systolic pressure level below 100 mm Hg, a history of kidney disease (pyelonephritis and glomerulonephritis), as well as in individuals with alcohol dependence.

Influence on ability to drive motor transport and control mechanisms

Acceptance of dipyrone does not affect the ability to drive vehicles or other mechanisms during the period of use of the drug.
The removal of analgin injections biotransformation products with urine can cause red staining of urine, which has no clinical significance and disappears after discontinuation of the drug.

Agranulocytosis

In case of an unexpected deterioration of the patient’s general condition during treatment with analginum, manifested by fever, inflammation of the mucous membranes of the mouth and pharynx (necrotic stomatitis, purulent necrotic angina), nose (sinusitis), elevated ESR, analgin should be stopped immediately, because . These symptoms may be associated with the development of agranulocytosis.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
Shelf life - 3 years. Do not use the drug after the expiration date.

Terms of sell

You don't need a prescription from a doctor to buy Analgin injections.