Orsoten caps 120mg #84

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What is Orsoten intended for?

The role of fats in obesity is not so great because they themselves are the least in dishes (as a percentage of other elements). But the modern food industry is increasingly using chemically modified fats and their mixtures instead of pure bases.
The effect of such “hybrids” on the metabolic system is still being studied, and there is already evidence of their ability to cause malfunctions and accelerated weight gain. And although in general reviews about Orsoten tablets speak of it as a drug with low effectiveness in terms of weight loss (not more than 10% of the total weight in three months), it can be more useful in fighting against obesity provoked by trans fats. other means.
Indications for the use of "Orsoten" do not relate to weight loss just to lose weight a little. Manufacturers see it as a drug designed to treat serious metabolic disorders, rather than mild imbalances, resolved by increasing physical activity and dietary restrictions. It is prescribed to the suffering:
    Obesity
    prediabetes (decreased glucose tolerance);
    cardiovascular disease.

Main effects

However, Orsoten is not suitable for the prevention of these diseases - only for their correction as part of complex therapy. Orlistat binds in the intestine with bile-split fatty acids and the enzymes involved in the digestion of fat, and then blocks them. All fat from food, including vegetable, animal and modified, remains in the intestine, since it cannot be absorbed by its walls into the blood. According to the manufacturer, this gives several effects.
    Decreased calorie intake. It is not as significant as when blocking the breakdown of carbohydrates, but noticeable for lovers of fat.
    Increased cell sensitivity to insulin. Insulin released in response to an increase in blood glucose activates glucose transporter proteins and corresponding cell receptors. As a result, cells become able to cleave this monosaccharide. This also applies to adipose tissue cells - adipocytes, which convert excess glucose into fat. At the same time, the number of adipocytes is growing, and they (especially fat in the abdomen) have the ability to synthesize adipocytokines - biologically active compounds that inhibit the activity of insulin and its receptors on the cell surface. The leading role in the development of insulin resistance is played by adipocytokine leptin. A decrease in the number of free triglycerides in the blood under the influence of orlistat leads to a slowdown in the growth of adipose tissue. Because of this, the concentration of “blockers” of insulin also decreases, and the sensitivity of cells to it is restored even with the previous level of human mobility.
    Reducing blood cholesterol. Due to the fact that fat is poorly absorbed in the intestine, food cholesterol also does not enter the bloodstream in full. Part of it is simply excreted in the feces. And although the liver in conditions of deficiency of food cholesterol can significantly increase its synthesis, the effect of the drug is considered positive in terms of reducing the rate of development of atherosclerosis. At the same time, some studies of atherosclerosis suggest that cholesterol deficiency is more likely to be harmful than beneficial, and dietary fats have almost no effect on vascular clogging.
The drug helps with chronic constipation. After all, non-absorbed fat is excreted in the feces, and the rectum is not intended for the formation / storage of masses with such a consistency, and seeks to get rid of them as soon as possible. However, this drug is not a "substitute" for other components of weight loss - diet and exercise. It only improves the result from them.

Side effects

"Orsoten" binds enzymes involved in the breakdown of fats in the intestinal cavity, as well as finished "products" of their activity, preventing the absorption of both in the blood. Subsequently, fats blocked in the intestine are excreted from the body with feces, which increases its fat content, can create a problem of gases and increased urge to defecate. According to the manufacturer, the drug does not affect the work of other organs of the body, since it does not contact them. But all the organs of the body are connected to each other, and the scheme presented by the manufacturer is greatly simplified, as evidenced by the side effects of Orsoten.
Side effects of "Orsoten" most often and most clearly affect the work of the intestine, especially its lower parts. They appear:
    increased gas formation;
    increased urge to defecate;
    difficulties in delaying emptying (up to incontinence);
    oily discharge from the anus.
These symptoms are due to the direct effect of orlistat, and their brightness decreases as the proportion of fat in the diet decreases. But together with Orsoten fats, it also blocks the absorption of fat-soluble vitamins from the intestines, including vitamins A, E and K, forming vitamin deficiency according to them.


Harm to the central nervous system, kidneys and gall bladder

The food cholesterol deficiency provoked by the drug harms the central nervous system and the synthesis of a number of hormones, which may result in:
    headache (observed in more than 30% of those taking Orsoten);
    dizziness and disorientation;
    unreasonable anxiety;
    sleep disorders
    slowing down tissue regeneration after injuries or sports.
With prolonged use, the means of manifestation from the central nervous system spontaneously decrease, and then disappear. There were no acute cases of damage to the central nervous system after losing weight on Orsoten. Drinking alcohol does not change the effect of the drug. But the list of its side effects also indicates more serious health consequences than transient swelling with migraine. Among them, gallstone disease and oxalaturia associated in some cases.
    Gallstones. Normally, bile acids, together with the fats cleaved by them, are absorbed into the bloodstream and returned to the liver. Reception of “Orsoten” breaks this chain, creating their deficit. Blocking cholesterol from food only complicates the matter, since the liver synthesizes bile from it. The concentration of bile acids in bile decreases, which increases the likelihood of stone formation. Most often - bilirubin. This dye is formed during the breakdown of red blood cells, it stains blood plasma, urine, bile and feces in tan shades. Excess bilirubin in the blood has a toxic effect on the liver, which processes it, and on the brain. Its excess in the composition of bile leads to inflammation of the walls of the gallbladder and the formation of stones.
    Oxalate stones. Oxalates are formed in the kidneys when oxalic acid metabolism is disturbed or when it is consumed in excess - with spinach, lettuce, sorrel and other acidic vegetables or berries. Oxalates are characteristic of supporters of a vegetarian diet or those who have been treated for atherosclerosis. Cholesterol-rich animal fats, blocked in the intestines by means of atherosclerosis or orlistat, bind in its cavity with calcium. It ceases to interact with oxalic acid located in the same place from food, which begins to enter the blood in a chemically pure form. Normally, this should not be, since calcium is also present in blood serum. When oxalic acid enters the blood, it binds to serum calcium. Calcium oxalates no longer occur in the intestine, from where they are excreted through the rectum, but in the bloodstream, and accumulate in the kidneys when you try to filter them out.
The transition to a plant diet recommended in dietary nutrition does not solve these problems and even exacerbates them - especially when combining a plant diet with Orsoten. The tool also makes it difficult to recover muscles after exertion, although increased physical activity is the key to losing weight, regardless of how many extra pounds you plan to lose.

Contraindications

Due to the irreversibility of some side effects (neurological and intestinal symptoms disappear after it is canceled, and gallstone disease does not) and serious interference with metabolism, the use of "Orsoten" is prohibited with the existing ones:
    oxalaturia - because it will increase with the beginning of the course;
    gallstones - the drug will provoke a sharp deterioration in gallstone disease;
    malabsorption syndrome - a violation of the general absorption of nutrients from the intestine into the blood, which can occur with a deficiency of digestive enzymes ("Orsoten" enhances these manifestations and can lead to complete digestibility of food components);
    chronic pancreatitis - especially arising as a complication of gallstone disease;
    nephrolithiasis - even if kidney stones are not oxalates, because metabolic disorders of some acids (like urinary with gout) negatively affect the metabolism of all the others;
    gout - taking “Orsoten” can aggravate its course or add problems in the form of gallstone disease.
Contraindications to the use of Orsoten also include pregnancy and breastfeeding, although orlistat is not absorbed from the intestine into the blood, and therefore does not penetrate the placenta or breast milk. The official explanation is the threat of deficiency of fat-soluble vitamins in the mother and child. But to this one must also add the sharply negative effect of Orsoten on cholesterol metabolism in the mother’s body.
One can argue about the role of cholesterol in the adult body. But it is the main component of breast milk and a resource for the growth of tissues of the baby’s body both in prenatal development and after birth. Therefore, it is still possible to lose weight with the help of "Orsoten" when planning pregnancy, but not after it.


Instructions for use

It does not matter how to drink Orsoten for the best effect, since this drug is still not very effective. The basis of excess weight (but not obesity) is "busting" on carbohydrates, not fats in food, the metabolism of which the drug does not affect. In this case, an overdose of the drug can lead to side effects and increase their brightness, but it will not accelerate weight loss.
The daily dosage of Orsoten tablets is 120 mg (one Orsoten tablet or two Orsoten Slim tablets) three times a day. You need to take the drug with food. If it is fat-free, you can not drink the product. In the regimen of taking "Orsoten" for weight loss, three or more months of its use are included. The total duration of treatment can be up to six months, which also reduces the feasibility of its use if you need to lose weight quickly.
Increasing the dosage of the drug, taking it before meals, after meals or on an empty stomach, taking other experimental steps to increase its effectiveness is fraught with irreparable damage to health. "Orsoten" binds only fats and bile acids, and only if they are present in the intestinal cavity. Its use during periods of absence or minimal maintenance there is completely useless and dangerous.

Mechanism of action

In the lumen of the digestive canal, Orsoten interacts with gastric and pancreatic lipases, blocking their active centers. Thus inactivated enzymes cease to participate in the breakdown of fats. Since whole lipid molecules are not able to be absorbed into the blood, they are excreted from the intestine unchanged. The amount of calories from food is reduced by an average of 30%, which leads to a decrease in body weight. The use of Orsoten is especially effective in patients who are used to sticking to a high-fat diet.
In addition to the main task, the drug:
    reduces the level of "bad" cholesterol in the blood,
    prevents the development of type II diabetes,
    lowers high blood pressure.
With prolonged use of Orsoten, a conditioned reflex forms in patients, which consists in the fact that a violation of the diet in the direction of fatty foods is strongly associated with unpleasant side effects of the drug (diarrhea and fatty stools). As a result, even with a rather weak motivation for weight loss, the patient involuntarily begins to adhere to a low-calorie diet.
With prolonged therapy with Orsoten, body weight decreases gradually, in accordance with nutritional standards. On average, in 3 months of treatment, patients lose from 5 to 8 extra pounds.

Metabolism and excretion

The drug acts in the digestive tract, practically not absorbed into the bloodstream. 8 hours after taking the drug, its concentration in the blood is about 6 ng / ml, which confirms the low absorption of the drug.
The main part of the drug is excreted in feces, and 83% of the dose taken is unchanged. A small amount breaks down in the intestinal wall to inactive products. Metabolites are excreted in the kidneys and bile.
The period of complete elimination of the drug from the body is from 3 to 5 days.

Terms of sell

You don't need a prescription from a doctor to buy Orsoten.