Efferalgan solution 30mg/ml 90ml

Instruction for Efferalgan solution

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PHARMACHOLOGIC EFFECT

Analgesic antipyretic. It has an analgesic and antipyretic effect. Inhibits COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of an anti-inflammatory effect.
It does not adversely affect water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa due to the lack of influence on the synthesis of prostaglandins in peripheral tissues. The possibility of methemoglobin formation is unlikely.

PHARMACOKINETICS

Data on the pharmacokinetics of the drug Efferalgan solution not provided.

INDICATIONS

For children aged 3 months to 12 years (with a body weight of 6-32 kg):
- increase in body temperature, including with acute respiratory infections, influenza, childhood infections, post-vaccination reactions;
- moderate or mild pain syndrome, incl. headache, toothache, muscle pain, neuralgia, pain from injuries and burns.

DOSAGE MODE

Efferalgan solution is prescribed orally 1-2 hours after a meal.
The average single dose depends on the body weight of the child and is 10-15 mg / kg body weight 3-4 times / day. The maximum daily dose is 60 mg / kg. The interval between doses is 4-6 hours.
For convenience and dosing accuracy, use a measuring spoon. The measuring spoon is marked with divisions indicating a single dose (15 mg / kg) for children with a body weight of 4, 8, 12 or 16 kg, respectively. Unmarked divisions correspond to a body weight of 6, 10 or 14 kg.
Children aged 3 months to 6 years (body weight 6-20 kg): fill a measuring spoon to the mark in accordance with the table. For example, if the child’s body weight is from 6 to 8 kg, then the measuring spoon should be filled to the mark corresponding to 6 kg.
Children aged 6 to 12 years (body weight 20-32 kg): fill the measuring spoon to the mark corresponding to 16 kg, then refill the measuring spoon to the mark in accordance with the table. For example, if the child’s body weight is from 20 to 22 kg, then you should fill the measuring spoon to the mark corresponding to 16 kg, then refill the measuring spoon to the mark of 4 kg.
Efferalgan solution can be given to a child without dilution or after dilution with water or milk.
The duration of treatment is 3 days when used as an antipyretic and up to 5 days as an analgesic. If you need longer administration of the drug, a doctor's consultation is required.

SIDE EFFECT

Allergic reactions: possible - skin rash, itching, Quincke's edema.
From the digestive system: possible - nausea, vomiting, abdominal pain; with prolonged use in high doses, a hepatotoxic effect is possible.
From the hemopoietic system: rarely - anemia, leukopenia, agranulocytosis, thrombocytopenia; with prolonged use in high doses, the development of methemoglobinemia and pancytopenia is possible.
Other: with prolonged use in high doses, a nephrotoxic effect is possible.

CONTRAINDICATIONS

- severe violations of the liver;
- severe renal impairment;
- blood diseases;
- deficiency of glucose-6-phosphate dehydrogenase;
- children's age up to 1 month;
- Hypersensitivity to the components of Efferalgan solution, especially parabens (methyl and propyl parahydroxybenzoate).
With caution, the drug should be used for impaired liver or kidney function of mild to moderate degree, with Gilbert syndrome.

SPECIAL INSTRUCTIONS

In order to avoid exceeding the maximum daily dose, you should not use Efferalgan solution simultaneously with other drugs containing paracetamol.
When using Efferalgan solution for more than 5-7 days, it is necessary to control the picture of peripheral blood and the functional state of the liver.
Paracetamol distorts the results of laboratory studies of glucose and uric acid in blood plasma.
If it is necessary to prescribe the drug to patients with diabetes mellitus or to patients on a diet with a low sugar content, it should be borne in mind that 1 ml of Efferalgan solution contains 0.335 g of sugar.
Persons caring for a sick child should be warned about the need to cancel the drug and consult a doctor in case of adverse reactions. A doctor’s consultation is also required in the absence of a therapeutic effect: continued fever for more than 3 days and pain for more than 5 days.

OVERDOSE

Symptoms: nausea, vomiting, stomach pain, sweating, pallor of the skin. After 1-2 days, signs of liver damage appear - pain in the liver, increased activity of hepatic transaminases in the blood, an increase in prothrombin time. In severe cases, liver failure, hepatonecrosis, encephalopathy and coma develop.
Treatment: cancel the drug, gastric lavage, administration of enterosorbents (activated charcoal, polyphepan) is recommended, iv administration of the N-acetylcysteine ​​antidote, methionine intake, clinical monitoring of the patient's condition.

DRUG INTERACTION

With the simultaneous use of Efferalgan solution with barbiturates, tricyclic antidepressants, anticonvulsants (phenytoin), zixorin, phenylbutazone, rifampicin, ethanol, the risk of hepatotoxicity significantly increases.
When taken with salicylates, the risk of nephrotoxicity significantly increases.
With simultaneous use with chloramphenicol (chloramphenicol), the toxicity of the latter increases.
Paracetamol enhances the effect of indirect anticoagulants.
Paracetamol reduces the effectiveness of uricosuric drugs.

Terms of sell

You don't need a prescription to buy Efferalgan solution.