Lozap tabs 100mg #90


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Lozap user manual

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Pharmacological properties

The drug Lozap got its name thanks to the active substance - losartan. This agent belongs to the group of type II angiotensive receptor antagonists used in the treatment of arterial hypertension. A feature of the action of losartan is the absence of an effect on the enzyme kinase II, which is a catalyst for the transformation of type I angiotensin into type II angiotensin. This drug is classified as a prodrug, since the active substance is a carboxylic acid metabolite, which is synthesized in the process of biotransformation reactions and it is he who has an antihypertensive effect. Given that Lozap is available in tablet form, the only route of consumption is oral. After ingestion, the maximum concentration of the active component in the blood is detected after 60 minutes, while its active metabolite acquires the greatest value after 4 hours. The period of elimination of carboxylic acid lasts 2 times longer (up to 8 hours) than losartan (about 3-4 hours). The pronounced hypotensive effect is noticeable after 21-30 days from the beginning of the therapeutic course.

Composition and form of release

The drug is available in the form of tablets with various dosages: • 12.5 mg No. 30, No. 60, No. 90; • 50 mg No. 30, No. 60, No. 90; • 100 mg No. 30, No. 60, No. 90. It is worth noting that Lozap Plus is also produced, which is an antihypertensive drug, but differs in composition from the previous drug. Lozap Plus combines lozaptan with hydrochlorothiazide, due to which the therapeutic effect occurs several times faster. The binders used are: cellulose, hypromellose, magnesium stearate, povidone, macrogol, dimethicone, dyes. The method and peculiarities of taking the drug by the patient are determined by the attending physician, based on the results of the laboratory tests obtained.

Indications for use

Indications for use is the need to treat such diseases of the cardiovascular system as: • hypertension; • chronic cardiovascular insufficiency; • diabetic nephropathy with severe proteinuria. Lozap is also prescribed as a prophylactic agent for the prevention of strokes and heart attacks in patients suffering from arterial hypertension and diagnosed with left cardiac hypertrophy.

Contraindications to treatment

Direct contraindications for taking Lozap are the presence of such conditions in the patient's history as: • pregnancy; • lactation period; • the age of patients not exceeding 18 years; • individual hypersensitivity to an active substance or auxiliary components. With special care, it is recommended to use the remedy for patients who have been diagnosed with: • a tendency to arterial hypotension; • water-electrolyte imbalance; • narrowing of the renal arteries; • reduced BCC (circulating blood volume); • chronic failure of the kidneys or liver.

Features of use during pregnancy

The use of the drug during pregnancy and lactation is strictly prohibited, since there is no reliable data on how the components of this pharmaceutical product can affect the body of a small child and whether the drug can penetrate into breast milk. If the use of a medicine is necessary for the mother's body, then the baby is recommended to be transferred to artificial feeding.

Features and method of reception

The dosage of the medicinal substance should be selected by a highly qualified doctor, individually for each patient. A single dose of the medicine is 1 tablet. In most clinical cases of using this drug, the daily dose does not exceed 50 mg. In the absence of the expected therapeutic effect, the amount of the drug can be increased to 100 mg. For the treatment of chronic cardiovascular insufficiency, the initial dose does not exceed 12.5 mg. The standard treatment regimen involves weekly dose increases, 12.5 mg, 25 mg, 50 mg. If the therapeutic effect is achieved, then the maintenance dose is left unchanged. You can use the medicine at a convenient time of the day, regardless of the time of the meal, but it is better to take the tablets in the morning. If the patient is taking diuretics in parallel, then the dose of Lozap should be reduced by 2 times. In the management of patients with insulin-dependent diabetes, against the background of proteinuria (protein in the urine), the initial dose is doubled.

Side effects of the medication

With the simultaneous treatment of other diseases, it is necessary to inform the doctor about the need for systemic administration of pharmaceuticals. With a properly selected dose of Lozap, patients tolerate the therapeutic course well. In some cases, it was reported that side effects developed in the form of: • dizziness, general weakness or loss of strength; • rapid heartbeat; • dyspeptic disorder; • headache, sleep phase disturbances, anxiety. Doctors insist that the above symptoms should not cause treatment withdrawal. Usually, the patient's condition returns to normal after 7-10 days of regular use.

Alcohol compatibility

The combination of Lozap with alcohol can be life-threatening for the patient. In addition to the effect on the cardiovascular system, losartan negatively affects the liver cells, increasing the toxic effects of alcohol.

How to store

It is recommended to store Lozap in original cardboard packaging along with instructions for use. Temperature range - up to + 25C. The guaranteed shelf life is 24 months from the date of production.

Terms of sell

A prescription is not required to buy Lozap.