Folic acid forte tabs 5mg #20

Folic acid forte user manual

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pharmachologic effect

Replenishes folic acid deficiency, stimulates erythropoiesis.
Folic acid - folacin, water soluble folate, vitamin B9. In the body, it is converted to tetrahydrofolic acid, which is necessary for the maturation of megaloblasts and their transformation into normoblasts. With its deficiency, a megaloblastic type of hematopoiesis develops. It occupies an important place in the exchange of purines and pyrimidines, the synthesis of nucleic acids, the metabolism of amino acids (glycine, methionine and histidine). After oral administration, folic acid, combining in the stomach with the Castle internal factor (specific glycoprotein), is absorbed in the upper part of the duodenum. Almost completely binds to plasma proteins. It is activated in the liver by the action of the enzyme dihydrofolate reductase, turning into tetrahydrofolic acid. Cmax in the blood is reached after 30-60 minutes. It is excreted by the kidneys both unchanged and in the form of metabolites.

Indications

Megaloblastic anemia, sprue, drug and radiation anemia and leukopenia, postresection anemia, chronic gastroenteritis, intestinal tuberculosis, folic acid deficiency.
Prevention of folic acid deficiency in the body (including during pregnancy and lactation).

Contraindications

Hypersensitivity to folic acid.
Folic acid forte can be used during pregnancy and lactation in recommended doses.

Side effects

Allergic reactions: bronchospasm, erythema, fever, skin rashes.

Interaction

With simultaneous use with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid decreases.
With the simultaneous use of folic acid reduces the effects of phenytoin, primidone, PASK, sulfasalazine, hormonal contraceptives for oral administration, chloramphenicol.
Folic acid increases phenytoin metabolism.

How to take, course of administration and dosage

For therapeutic purposes, adults - 5 mg / day; children - in smaller doses, depending on age. The course of treatment is 20-30 days.
To prevent folic acid deficiency in the body, it is used in doses of 20-50 mcg / day.
The daily need for folic acid is for children 1-6 months - 25 micrograms, 6-12 months - 35 micrograms, 1-3 years old - 50 micrograms, 4-6 years old - 75 micrograms, 7-10 years old - 100 micrograms, 11- 14 years old - 150 mcg, 15 years and older - 200 mcg.
During pregnancy - 400 mcg / day, during lactation - 300 mcg / day.

Special instructions

With pernicious anemia, folic acid should be used only in conjunction with cyanocobalamin, since folic acid, stimulating hematopoiesis, does not prevent the development of neurological complications (including funicular myelosis). Long-term use of folic acid (especially in high doses) is not recommended because of the risk of lowering the concentration of cyanocobalamin in the blood.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C

Terms of sell

You don't need a prescription to buy Folic acid forte.