Brustan tabs #10

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Brustan user manual

You can buy Brustan here

Indications

Feverish reactions in acute respiratory diseases, influenza, post-vaccination reactions and other infectious and inflammatory diseases.
Pain syndrome of weak or moderate intensity, including: headache, toothache, migraine, neuralgia, lumbago, myalgia, fibrositis, tendovaginitis, arthralgia in rheumatoid arthritis, osteoarthrosis, gout, spondyloarthritis, etc., pain in diseases of the ENT, soft tissue and musculoskeletal injuries (stretching, bruises, sprains, fractures, etc.), postoperative pain, algomenorrhea.

Contraindications for Brustan

Hypersensitivity to ibuprofen, paracetamol, acetylsalicylic acid or other NSAIDs, as well as to other components of Brustan; A history of an attack of bronchial obstruction, urticaria, rhinitis, triggered by the administration of acetylsalicylic acid (salicylates) or other NSAIDs (complete or incomplete intolerance of acetylsalicylic acid: rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma). Period after coronary artery bypass surgery. Erosive and ulcerative lesions of the gastrointestinal tract, active gastric bleeding. Inflammatory bowel disease. State of hypocoagulation, cerebrovascular bleeding. Severe renal and / or liver failure, confirmed hyperkalemia. Pregnancy, lactation. Children's age up to 12 years (this dosage form).

Carefully

Congestive heart failure, arterial hypertension, coronary heart disease, cerebrovascular diseases, dyslipidemia, diabetes mellitus, peripheral artery disease, smoking, frequent use of alcohol, hyperbilirubinemia, cirrhosis of the liver with portal hypertension, hepatic and / or renal failure, nephrosis, pregnancy, hepatic cirrhosis, portal hypertension, hepatic and / or renal insufficiency, nephrotic syndrome. II trimesters, advanced age, deficiency of glucose-6-phosphate dehydrogenase, peptic ulcer and 12 duodenal ulcer (in history), gastritis, blood diseases of unknown etio ogii (leucopenia and anemia).


Composition

Active substances in 1 tablet: Ibuprofen 400 mg + Paracetamol 325 mg.
Release form: Tablets, film coated, №10.
Brustan is taken orally after a meal.
Adults and children over 15 years of age: Brustan is taken 1 tablet 3-4 times a day with an interval of 6-8 hours (no more than 4 times a day!).
Children from 12 to 15 years old (body weight more than 40 kg): 1 tablet 3 times a day.
If the fever persists for more than 3 days, you should consult with your doctor.
The duration of treatment is determined by the doctor depending on the therapeutic effect and the nature of the disease.

Interactions

Inductors of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe hepatotoxic reactions.
Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action.
Reduces the hypotensive activity of vasodilators (including blockers of "slow" calcium channels and ACE inhibitors), natriuric and diuretic - furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (increased risk of hemorrhagic complications), ulcerogenic effect with bleeding glucocorticosteroids, colchicine, estrogen, ethanol; enhances the effect of oral hypoglycemic drugs and insulin.
Antacids and colestyramine reduce the absorption of ibuprofen .. Increases blood concentration of digoxin, lithium preparations and methotrexate
Caffeine enhances the analgesic effect.
With the simultaneous appointment of the active ingredient Brustan - ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (ASK) (after starting ibuprofen, it is possible to increase the incidence of acute coronary insufficiency in patients who receive small doses of ASA as an antiplatelet agent).
When administered with anticoagulants and thrombolytic drugs (alteplazy, streptokinase, urokinase), serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) increases the risk of serious gastrointestinal bleeding.
Cefamendol, cefaperazon, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia.
Myelotoxic drugs increase the hematotoxicity of Brustan.
Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increase in nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects. Drugs that block tubular secretion, reduce excretion and increase the plasma concentration of ibuprofen.


Side effects of Brustan

When using the drug side effects are rarely observed, however, the following side effects may occur:
Gastrointestinal tract: NSAIDs gastropathy (nausea, vomiting, heartburn, abdominal pain, constipation, flatulence, loss of appetite, rarely ulceration of the gastrointestinal tract, in some cases complicated by bleeding and perforation), irritation or dryness of the oral mucosa, pain in the mouth ulceration of the mucous membrane of the gums
Hepato-biliary system: hepatitis
Allergic reactions: skin rash (usually erythematous or urticaria), pruritus, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme (including edema of the erythema syndrome (including SJS syndrome, including a fever, dystrophy, erythema and erythema, including anemia) Lyell), eosinophilia, allergic rhinitis.
Cardiovascular system: heart failure, tachycardia, increased blood pressure.
Central and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases)
Organs of hematopoiesis: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
Respiratory system: shortness of breath, bronchospasm.
Sense organs: hearing impairment (ringing or tinnitus), impaired vision (toxic optic neuritis, blurred vision or diplopia, dryness and eye irritation, conjunctival edema and age of allergic genesis, scotoma)
Urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis
Laboratory indicators: bleeding time, serum creatinine concentration, liver transaminase activity (may increase); serum glucose concentration, creatinine clearance, hematocrit or hemoglobin (may decrease).

Special instructions

Treatment with Brustan should be carried out in the minimum effective dose, the shortest possible short course.
During treatment, control of the pattern of peripheral blood and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, close monitoring is shown, including esophagogastroduodenoscopy, a blood test with hemoglobin, hematocrit, and fecal occult blood analysis. To prevent the development of NSAIDs-gastropathy, it is recommended to combine prostaglandin E (misoprostol) with drugs. Patients should refrain from all activities that require increased attention, rapid mental and motor responses. During the period of treatment is not recommended alcohol intake (ethanol).
When taken simultaneously with indirect anticoagulants, it is necessary to control the blood coagulation system.

Terms of sell

The prescription is not required to buy Brustan.